Rhythmone SR Sustained-release Capsule 325 mg (Propafenone Hydrochloride)

Adult dose

The dose of this medicine should be adjusted according to each patient's response and tolerability. Individual titration to the maintenance dose must be strictly managed by a cardiologist under cardiac monitoring, including electrocardiogram (ECG) monitoring and repeated blood pressure measurements. This medicine may be taken with or without food. This medicine or its contents should be taken whole with water. Do not chew or crush the contents of this medicine. Adults: The starting dose is 225mg twice daily, 12 hours apart. After at least 5 days of treatment, the dose may be increased to 325mg twice daily. If an additional therapeutic effect is needed, the dose may be increased to 425mg per dose at 12-hour intervals after at least 5 more days of treatment. Dose reduction should be considered in patients who develop significant QRS widening or second- or third-degree atrioventricular block.

This medication is an antiarrhythmic agent used to regulate heart rhythms. There is an increased risk of death if this medication is administered to patients with non-life-threatening ventricular arrhythmias who have recently experienced a myocardial infarction. It should not be used in patients with severely reduced heart function or certain cardiac conduction disorders, and administration should be avoided in patients with severe heart failure or very low cardiac output. This medication should be administered cautiously in patients with impaired liver or kidney function, in elderly patients, and in patients with asthma or chronic obstructive pulmonary disease. Regular electrocardiographic examinations and close monitoring of the patient's condition are required. Various adverse reactions such as dizziness, cardiac irregularities, low blood pressure, gastrointestinal symptoms, and skin rashes may occur during treatment, and patients should be immediately informed of any such symptoms. This medication may interact with other drugs; therefore, if any other medications are being taken, the healthcare provider must be informed. Caution is particularly necessary when used in combination with specific antibiotics, antidepressants, or anticoagulants. Pregnant or breastfeeding women should consult with their doctor regarding the use of this drug, and decisions should be made carefully considering the potential effects on the fetus or neonate. In pediatric patients, the safety and efficacy of this drug have not been sufficiently established, and it is not recommended. In case of overdose, there may be cardiac dysfunction, central nervous system abnormalities, and in severe cases, life-threatening conditions; therefore, adherence to the prescribed dosage must be strict, and if overdose is suspected, emergency care should be sought immediately. This medication must be kept out of the reach of children and care should be taken not to transfer it to another container.

• Thrombocytopenia
• agranulocytosis
• leukopenia
• neutropenia
• hypersensitivity
• decreased appetite
• anxiety
• sleep disorders
• nightmares
• confusion

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and it is vital to maintain a storage temperature between 1 and 30 degrees Celsius. Proper storage can help maintain the effectiveness of the medication.

Appearance

A white to nearly white, opaque hard capsule containing a sustained-release microtablet that is spherical and convex on both sides.

Package unit

50 capsules (10 capsules/PTP x 5)