Nephsol Injection

Adult administration

Generally, 250 to 500 mL (1.6 to 3.2 g of nitrogen, 13.4 to 26.8 g of essential amino acids) is administered via intravenous drip per day. If caloric sources are administered simultaneously, mix 250 mL of this medication with 500 mL of 70% dextrose under sterile conditions. The administration rate should generally start at 20 to 30 mL per hour, increasing to a maximum of 60 to 100 mL over 24 hours.

Child administration

Start with a lower total daily amount on the first day and gradually increase, not exceeding 1 g of essential amino acids per kg of body weight per day.

This medicine should be used only as directed by a physician. It should not be administered to patients with hepatic dysfunction such as hepatic coma, severe electrolyte and acid-base imbalances, reduced blood circulation, hyperammonemia, and those with congenital amino acid metabolism disorders. Caution should be exercised in patients with congestive heart failure, children, underweight patients, patients relying heavily on nitrogen sources, patients with gastrointestinal bleeding or at risk of hyperammonemia. Additionally, this medication contains sodium bisulfite, which may cause allergic reactions or asthma attacks in some patients, so care should be taken. During administration, side effects such as itching, rash, nausea, vomiting, and palpitations may occur. Rapid administration in large volumes may cause acidosis. Liver function tests may show elevated levels, and changes in blood urea nitrogen and ammonia levels may occur, with an increased risk of thrombophlebitis. Particularly in patients with severe gastrointestinal bleeding or in children, hyperammonemia may occur, requiring caution. This medication is used for acute patients requiring strict low-protein diets, dialysis patients, and those unable to take oral medication. During administration, blood fluid, electrolyte, and acid-base status, as well as BUN levels, must be monitored regularly, and diabetic patients should control their blood sugar levels. If only amino acid solution is administered, ketones may accumulate, so it is advisable to administer it with carbohydrates. This medication may generate toxic substances when mixed with other drugs, so only drugs confirmed for compatibility should be mixed carefully, and the mixture should be used immediately after preparation. Overdosage may lead to side effects or edema, so administration should be stopped or the dosage reduced for slow administration. Care should be taken for electrolyte balance during administration, and it should be infused slowly intravenously; rapid infusion may cause chills or vomiting. This medication should always be prepared in a sterile condition and must be stored properly to prevent deterioration, with any remaining solution not to be reused.

Serious side effects

• Generalized urticaria
• asthma attacks
• hyperammonemia

Mild side effects

• Generalized itching
• rash
• nausea
• vomiting
• loss of appetite
• chest discomfort
• palpitations
• acidosis
• elevated AST and ALT
• increased BUN

This medication should be stored in a sealed container to prevent exposure to air, and it is safest to store it at room temperature between 1 degree and 30 degrees Celsius. Proper storage will maintain the drug's effectiveness and prevent deterioration.

Appearance

A colorless to pale yellow transparent liquid contained in a colorless transparent polypropylene aqueous injection container.

Package unit

250 mL