Crabutin Tablets 375 mg (Amoxicillin·Clavulanic Acid Potassium (2:1))

Adult dose

For adults and pediatric patients aged 12 years or older or weighing over 40 kg, the dosage is 250 mg/125 mg of Amoxicillin/Clavulanic Acid Potassium administered orally three times a day at 8-hour intervals. In cases of severe and respiratory infections, the dosage can be increased to 500 mg/125 mg per administration. In patients with renal impairment, dosage adjustments should be made based on creatinine clearance. - Creatinine clearance 10-30 mL/min: 250-500 mg of amoxicillin every 12 hours orally. - 10 mL/min or less: 250 mg of amoxicillin every 24 hours, being careful not to exceed the dosage. - For children: dosage adjustments should be made in the same manner. - However, in cases of dental infections, administer 250 mg of amoxicillin, three times a day for 5 days.

Child dose

For children aged 12 years or older or weighing over 40 kg, the dosage is the same as adults: 250 mg/125 mg of Amoxicillin/Clavulanic Acid Potassium orally three times a day at 8-hour intervals. For pediatric patients with renal impairment

This medication contains beta-lactam antibiotics that belong to the penicillin group. Therefore, patients with a history of allergic reactions to this medication or similar drugs should not use it. Particular caution is necessary for those with a history of hypersensitivity reactions such as anaphylaxis, severe skin reactions, or shock. Additionally, patients with infectious mononucleosis or lymphocytic leukemia have a higher risk of side effects like rash and should avoid its use. Patients with previous liver function issues should also exercise caution, as taking this medication may reactivate liver dysfunction. Patients with impaired liver or kidney function may have increased concentrations of this medication in their bodies, so dosage and administration intervals should be adjusted according to a physician's instructions. Allergy-prone individuals or those with digestive diseases, elderly patients, and malnourished patients should also use this medication with caution. During the course of this medication, if abnormal symptoms appear, such as diarrhea, abdominal pain, rash, or shortness of breath, it is important to stop taking the medication immediately and consult a doctor. Immediate action is necessary if diarrhea persists or severe abdominal pain occurs, as serious gastrointestinal diseases such as pseudomembranous colitis may develop. This medication can cause a variety of side effects such as liver dysfunction, blood disorders, kidney issues, and skin rashes; therefore, it is important to have regular blood tests and liver function tests when taking it long-term. Women who are pregnant or breastfeeding should only take this medication under medical supervision when necessary, particularly avoiding it in the first three months of pregnancy. Moreover, this medication can interact with other drugs, so patients must inform their medical staff about any currently taken medications, especially when using anticoagulants, antibiotics, and anti-inflammatories. Finally, this medication is only recommended for children aged 12 years or older or those weighing over 40 kg, and it should be stored in a dry place below 25 degrees.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweats, paleness, anaphylaxis, Stevens-Johnson syndrome (skin and mucous membrane syndrome), shock, severe allergic reactions, severe skin adverse reactions, blistering dermatitis, acute generalized exanthematous pustulosis, respiratory distress, asthma attacks, bronchospasm, laryngeal edema, anaphylactic shock, severe neurological abnormalities (severe headache, seizures, altered consciousness, visual disturbances)

Mild side effects

Diarrhea, pseudomembranous colitis, dyspepsia, stomatitis, gastritis, glossitis, black hairy tongue, nausea, vomiting, loss of appetite, abdominal pain, bloating, constipation, colonic pain, hyperacidity, loose stools, dry mouth, acute pancreatitis, candidiasis, antibiotic-associated colitis, elevation of AST, elevation of ALT, elevation of ALP, elevation of LDH, increase in serum bilirubin, hepatitis, cholestatic jaundice, itching, erythema multiforme, blood abnormalities (leukopenia, thrombocytopenia)

This medication should be stored in a sealed container to prevent moisture and should be kept in a dry place below 25 degrees to maintain its efficacy. Therefore, it is important to avoid exposure to direct sunlight or humid environments during storage.

Appearance

White to almost white oval film-coated tablets

Package unit

100 tablets (10 tablets/PTP x 10)