Crabutin Duo Dry Syrup (Amoxicillin · Clavulanate Potassium (7:1))

Adult dose

For recurrent tonsillitis or other upper respiratory infections, lower respiratory infections, urinary tract infections, and mild to moderate skin and soft tissue infections, amoxicillin/clavulanate potassium is taken twice daily at 25 mg/3.6 mg per kg of body weight. For severe infections such as otitis media, sinusitis, lower respiratory infections like bronchial pneumonia, and urinary tract infections, amoxicillin/clavulanate potassium is taken twice daily at 45 mg/6.4 mg per kg of body weight.

Child dose

The 7:1 syrup is not suitable for children under 2 months of age and is also not suitable for children with renal failure.

This medication is a beta-lactam antibiotic; individuals allergic to penicillins or cephalosporins may experience severe hypersensitivity reactions and should not take it. Those with infectious mononucleosis or lymphocytic leukemia are at higher risk of developing rashes and should exercise caution. Patients with a history of liver dysfunction or jaundice due to this medication or penicillin should not use it due to the risk of recurrence. Patients with compromised liver function should use this medication cautiously, as it may worsen liver function. Patients with moderate or severe kidney dysfunction may retain the drug longer, increasing the risk of side effects, thus requiring adjustment in dosage and dosing intervals. Individuals with a history of allergies or a family history of allergies should be particularly cautious before administration, as severe vomiting or diarrhea may impair drug absorption. Gastrointestinal symptoms such as diarrhea, abdominal pain, nausea, and vomiting may occur during treatment; in severe cases, serious conditions like pseudomembranous colitis may develop, necessitating immediate discontinuation and consultation with a physician if symptoms are severe. Regular liver function tests are necessary for patients taking the drug long-term, as there may be an increase in liver function test values or, rarely, symptoms of hepatitis and jaundice. Serious skin reactions such as rashes, urticaria, and in severe cases Steven-Johnson syndrome may develop, requiring immediate discontinuation of the medication if a rash occurs. Blood tests may reveal abnormalities such as leukopenia or thrombocytopenia, necessitating further investigation if any unusual symptoms appear. Rarely, central nervous system symptoms such as anxiety, confusion, or seizures may occur, particularly in patients with impaired kidney function. Pregnant or nursing women should always consult a physician before administration, and use should preferably be avoided during the first three months of pregnancy. Elderly patients are at risk of bleeding due to decreased kidney function and vitamin K deficiency, so careful monitoring of dosage and frequency is necessary. This medication may interact with other drugs, so patients taking anticoagulants, certain antibiotics, anti-inflammatory agents, or anticancer medications must inform their physician or pharmacist. In case of overdose, gastrointestinal symptoms, kidney function abnormalities, or seizures may occur, necessitating immediate medical attention. This medication should be stored refrigerated after preparation and consumed within 7 days, and must be well shaken before use.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash accompanied by high fever, blisters, skin peeling, pain in the oral/eye mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory distress with cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination

Mild side effects

Diarrhea, pseudomembranous colitis, indigestion, stomatitis, gastritis, glossitis, black hairy tongue, nausea, vomiting, appetite loss, abdominal pain, abdominal bloating, constipation, colonic pain, hyperacidity, loose stools, dry mouth, acute pancreatitis, candidiasis, colitis, itching, erythema multiforme, skin and mucous membrane syndrome, toxic epidermal necrolysis, vesicular exanthema, acute generalized exanthematous pustulosis, eosinophilia, angioedema, serum sickness syndrome, vasculitis, bronchospasm, laryngeal edema,

This medication should be stored in a tightly sealed container to prevent air or moisture ingress, kept in a cool place between 1 degree and 25 degrees Celsius. It is important to avoid direct sunlight or high temperatures and to keep it in a safe place out of reach of children.

Appearance

A whitish powder with a distinct smell, used as a syrup that is dissolved before use

Package unit

50ml x 1, 10 bottles