Klatron Tablet 500 mg (Clarithromycin)

Adult dose

○ Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer this medicine to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it should be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children 12 years of age and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medicine should not be administered to patients with certain medications or diseases. For example, it should not be used in patients who are allergic to it or have certain heart problems, severe liver or kidney dysfunction. Additionally, it is safer for pregnant or breastfeeding women to avoid this medication. There is a risk of severe allergic reactions, skin disorders, gastrointestinal disturbances, liver dysfunction, kidney issues, and neurological abnormalities while using this medication; therefore, if these symptoms occur, the patient should consult a doctor immediately. Patients with a history of heart diseases, such as arrhythmias or QT prolongation, should be cautious while taking this medication. Furthermore, this medication can interact with various other drugs, so it is vital to inform the doctor or pharmacist if other medications are being taken. Elderly patients or those with decreased liver or kidney function may require dosage adjustment. During the period of taking this medication, it is vital to adhere strictly to the prescribed duration and dosage to prevent the development of resistant bacteria and not to cease taking it even if symptoms improve. Also, if there are persistent diarrhea or abdominal pain after taking this medication, it could indicate a serious intestinal condition such as pseudomembranous colitis; therefore, the patient should consult a healthcare provider immediately. Pregnant or breastfeeding women should avoid this medication, and if it must be taken, it is safe to discontinue breastfeeding. The use of this drug in children is restricted based on age, so consult a physician for pediatric patients. In cases of overdose, gastrointestinal disturbances or mental symptoms may occur, so it is necessary to visit a medical institution immediately; be aware that the drug may not be removed through hemodialysis. Finally, this medication should be stored away from direct sunlight and kept at room temperature; refrigeration should be avoided.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, hives, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, convulsion type, dry mouth, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, stool discoloration, membrane colitis, hemorrhagic colitis, bloody stool, fever, cough, eosinophilia, eosinophilic lung infiltrates, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, taste loss, smell loss, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, increased total bilirubin, loss of appetite, dark urine, itching, abdominal tenderness, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, oliguria, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, hearing impairment, hypoglycemia, tinnitus, hearing loss, vomiting, purpuric rash, acute generalized exanthematous pustulosis, cellulitis, candidiasis, gastroenteritis, infection, vaginal infection, angioedema, decreased appetite, hypoglycemia, insomnia, nervous hypersensitivity, confusion state, abnormal dreams, mania, headache, loss of consciousness, dyskinesia, non-vertiginous dizziness, drowsiness, tremor, vestibular dizziness, hearing loss, cardiac arrest, atrial fibrillation, premature contractions, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, biliary stasis, hepatitis, increased alanine aminotransferase, increased aspartate aminotransferase, increased gamma-glutamyl transferase, liver failure, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schönlein purpura, muscle cramps, musculoskeletal stiffness, myopathy, increased blood urea, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, changes in mental state, obsessive behavior, hypokalemia, hypoxemia

This medication is sensitive to light and should be stored in a sealed container that blocks light. It is important to maintain a storage temperature between 15°C and 30°C.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle