Clopidogrel Tablets (Clopidogrel Sulfate)

Adult dose

For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer clopidogrel orally at a dosage of 75 mg once daily. For patients with acute coronary syndrome (unstable angina or non-ST elevation myocardial infarction), initiate with a loading dose of 300 mg taken orally once daily on the first day and continue with a maintenance dose of 75 mg once daily thereafter. In this case, aspirin 75 – 325 mg should be co-administered once daily.

This medication prevents platelet aggregation in the blood and helps prevent thrombus formation. People with genetic deficiencies in a specific enzyme (CYP2C19) may experience reduced efficacy of this drug, and in such cases, treatment options should be reconsidered or changed to other medications. Co-administration with medications that activate certain enzymes may increase the effect of this drug excessively, leading to an elevated risk of bleeding, thus co-use is not recommended. Patients with allergies to this medication or its components, those with bleeding, severe liver impairment, nursing women, or those with genetic issues such as lactose intolerance should not take this medication. Patients at high risk for bleeding or those scheduled for surgery should inform their healthcare provider immediately if any bleeding symptoms occur during the use of this drug and should discontinue it 5-7 days prior to surgery. Additionally, the use of this drug in conjunction with other bleeding risk medications (e.g., warfarin, aspirin, non-steroidal anti-inflammatory drugs, etc.) may increase the risk of bleeding, thus caution is advised. This medication can rarely cause a serious blood disorder called thrombotic thrombocytopenic purpura (TTP), so if sudden bleeding, fever, or neurological symptoms occur, consult healthcare personnel immediately. Bleeding may take longer to stop while taking this medication, so if there is a bleeding site or if bleeding does not stop, inform healthcare personnel immediately. While this drug is reported to pose a low risk to the fetus during pregnancy, the risk of bleeding may increase during delivery, so it is advisable to discontinue it before childbirth. For nursing mothers, since this drug may pass into breast milk, careful consideration regarding breastfeeding is necessary. Elderly patients or those with impaired kidney or liver function are at higher risk of bleeding and should be monitored closely under a doctor's instruction while taking this medication. Overdose may increase bleeding risk, so it is essential to adhere strictly to the prescribed dosage and seek immediate medical assistance if an overdose occurs. This medication has not been sufficiently studied for safety and efficacy in children, thus its use is not recommended. While taking this drug, there may be interactions with other medications, so it is essential to inform healthcare personnel about taking this drug before starting any new medication or undergoing surgery. Finally, keep this medication out of the reach of children and avoid transferring it to another container.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, peeling skin, pain in mouth/eyes, difficulty breathing or breathlessness, asthma attack, respiratory issues accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme fatigue, sudden and very severe headache, thunderclap headache, seizures, confusion, visual disturbances, syncope.

Mild side effects

• Chest pain
• accidental injury
• influenza-like illness
• pain
• fatigue
• edema
• hypertension
• headache
• dizziness
• abdominal pain

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. It is important to maintain the storage temperature between 1 and 30 degrees Celsius. This ensures that the medication retains its efficacy and can be used safely.

Appearance

Pink, round, film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle