Nakozol 100 mg (Itraconazole)

Adult dose

To increase absorption, this medicine should preferably be administered immediately after a meal. 1. Short-term treatment This medicine continues to have a therapeutic effect in skin tissue even after treatment is discontinued. Therefore, the final clinical and mycological response should preferably be assessed 2～4 weeks after completion of the prescribed treatment. 1) Candidal vaginitis: Administer itraconazole 200 mg twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Pityriasis versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis, tinea cruris: Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital), tinea pedis (interdigital): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palmar), tinea pedis (plantar): Administer 100 mg once daily for 30 days or 200 mg twice daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200 mg twice daily for 1 week, followed by a 3-week drug-free period; this constitutes one cycle. Administer up to 2 cycles for infection limited to the fingernails and up to 3 cycles for toenail infection. Site of onychomycosis Week 1: Treatment Weeks 2, 3, 4: No treatment Week 5: Treatment Weeks 6, 7, 8: No treatment Week 9: Treatment Toenails (with or without concomitant fingernail infection) Treatment No treatment Treatment No treatment Treatment Fingernails Treatment No treatment Treatment Or 2) Continuous therapy Administer 200 mg once daily for 3 months. The therapeutic effect continues for 3 months for fingernails and 6 months for toenails after the end of treatment. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia or AIDS or those who have undergone organ transplantation, the oral bioavailability of this medicine may be reduced; therefore, double the dose if necessary. Aspergillosis: 200mg once daily, 2～5 months. For invasive or disseminated disease, increase to 200mg twice daily. Candidiasis: 100～200mg once daily, 3 weeks～7 months. Cryptococcal meningitis: 200mg twice daily, 2 months～1 year. Maintenance therapy: 200mg once daily. Paracoccidioidomycosis: 100mg once daily, 6 months.

This medication should not be used in patients with compromised heart function, especially those with congestive heart failure, as it can be life-threatening. If symptoms of heart failure occur while taking this medication, it should be discontinued immediately. It must not be used in individuals with a history of allergy or hypersensitivity to this drug. Additionally, it can interact with several other medications, so it should not be taken together with certain drugs. Women who are pregnant or may become pregnant, as well as nursing mothers, should avoid taking this medication. Patients with lactose intolerance or specific genetic metabolic disorders should also not use this medication. Patients with compromised liver or kidney function, weakened immune systems, or a history of neuropathy due to this medication should use it with caution. This drug may cause gastrointestinal and neurological side effects such as headache, nausea, and abdominal pain, and less commonly, severe side effects such as liver dysfunction, skin rash, and cardiac arrhythmias may occur. Report any abnormal symptoms to a healthcare professional immediately. There are many interactions with other medications, which can increase the risk of side effects when taken together, so inform your healthcare provider about all medications you are taking. Special caution is necessary when used in combination with heart medications, anticoagulants, antipsychotics, anticancer drugs, and other pain relievers. Take it with acidic beverages as low stomach acidity can reduce absorption. Caution is required while driving or operating machinery as side effects like dizziness, visual disturbances, and hearing loss may occur. In case of overdose, there are no specific antidotes, so symptomatic treatment should be taken, and it is not removed by hemodialysis. Keep out of reach of children and store it in its original container to maintain quality.

• Headache
• nausea
• abdominal pain
• rhinitis
• sinusitis
• upper respiratory infection
• leukopenia
• hypersensitivity
• taste disorder
• sensory loss

This medication should be stored in a tightly sealed container to prevent air ingress, ideally at room temperature between 1 degree and 30 degrees. Storing it this way helps maintain the drug's effectiveness for a long time.

Appearance

White to light white oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle