Medication info

Raprel Tablet (Naprolin Oxalate)

Prescription medicationTabletOralApproval withdrawn
Ingredient · strength
Nafronyl Oxalate›100mg / 1 tablet
Manufacturer / importer
Korea Pharma Co., Ltd.
Appearance
White round film-coated tablets
Packaging
30 tablets/bottle, 100 tablets/bottle
Approval status
Approval withdrawn

MFDS item code 201308393 · Notified 2013.07.26

This product's status changed to Approval withdrawn on 2024.03.26. It may no longer be sold, so consult a doctor or pharmacist before taking it.

Summary

Main use
Improvement of peripheral vascular disorders
Who takes it
Adults
Adult dose
Administer 100 mg of nafronyl oxalate orally per dose, 3 times daily.

Ingredients

Manufacturer
Korea Pharma Co., Ltd.

Efficacy & effects

Improvement of peripheral vascular disorders

  • Peripheral vascular disorder
View approved original text

Peripheral vascular disorder refers to a state where blood circulation in peripheral areas such as hands or feet is not smooth. This can primarily occur due to narrowing or blockage of blood vessels, and symptoms may include numbness, pain, and cold sensation. This medication is used to improve such peripheral vascular disorders, promote smooth blood circulation, and alleviate symptoms.

How to take

Adult dose

Administer 100 mg of nafronyl oxalate orally per dose, 3 times daily.

Precautions

This medication should not be used in patients with specific health conditions. For example, it should not be administered to patients suffering from acute myocardial infarction or acute heart attack, patients with severe bleeding from initial injuries, or patients with orthostatic dysregulation. Furthermore, it should not be given to individuals with allergic reactions to this medication, patients with a history of hyperoxaluria or recurrent calcium kidney stones, patients with congestive heart failure or severe cardiac conduction defects, angina, or hypotension. It is also not recommended for patients with severely impaired liver function, those at risk of seizures, pregnant women, or women who may become pregnant, and nursing mothers. This medication should be used cautiously in patients with poor kidney function and patients with coronary atherosclerosis. Taking this medication can affect the mental nervous system and may lead to symptoms such as brain convulsions, sensory abnormalities, anxiety, drowsiness, insomnia, fatigue, headaches, and dizziness. In the gastrointestinal system, side effects may include loss of appetite, esophagitis, vomiting, nausea, abdominal pain, and diarrhea. Allergic reactions can manifest as hives, angioedema, and rarely skin rashes, while liver function abnormalities can cause hepatitis, jaundice, acute hepatocellular necrosis, increased liver enzymes, and liver failure. In the kidneys, urinary disorders and calcium oxalate kidney stones may occur, and in the cardiovascular system, blood pressure reduction, orthostatic dysregulation, arrhythmia, angina, syncope, and peripheral edema may occur. Additionally, there may be an increase in blood sugar levels, so caution is needed. This medication is not for the treatment of high blood pressure and should not be used to control blood pressure. When taking this medication, adequate hydration should be maintained to prevent the formation of calcium oxalate kidney stones. Caution is advised as taking this medication without fluids before bedtime may lead to esophagitis. When taken in conjunction with antihypertensives, the hypotensive effect may be intensified, and when used with arrhythmic agents, its effect may be enhanced, so consultation with a physician is necessary. It is safest for pregnant or nursing women not to take this medication. In cases of overdose, it may cause cardiac rhythm suppression and convulsions, so it is important to inform medical personnel immediately and to receive appropriate treatment. Treatment may include gastric lavage, administration of Activated Charcoal, cardiovascular and respiratory monitoring, and use of an electric pacemaker and medication if necessary.

Side effects

  • Cerebral convulsions
  • sensory abnormalities
  • anxiety
  • drowsiness
  • insomnia
  • fatigue
  • headache
  • dizziness
  • loss of appetite
  • esophagitis
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  • vomiting
  • nausea
  • abdominal pain
  • diarrhea
  • hives
  • angioedema
  • rash
  • hepatitis
  • bile acid stagnation jaundice
  • acute hepatocyte necrosis
  • increased liver enzymes
  • liver failure
  • urinary disorders
  • calcium oxalate kidney stones
  • hypotension
  • orthostatic control disorders
  • arrhythmia
  • angina
  • syncope
  • peripheral edema
  • increased blood sugar

Not everyone experiences these, and they can vary from person to person.

Storage

This medication is sensitive to light, so it should be stored in a container that protects it from light. Additionally, it should be stored safely at room temperature between 1 degree to 30 degrees Celsius.

Appearance and packaging

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.