Clarithromycin 500 mg Tablet

Adult dose

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily; for severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily; for severe infections, administer 250mg (potency) twice daily. Do not administer for more than 14 days to these patients. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it should be coadministered with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14), and administer omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be administered to certain patients. For example, those allergic to the ingredients of this drug or similar antibiotics, patients with severe cardiac arrhythmias, or those with severely impaired liver and kidney functions may face risks using this drug. Additionally, pregnant or breastfeeding women should not take this medication. Serious side effects may occur when taken with specific other medications, so it is crucial to consult a healthcare provider or pharmacist if currently taking other medications. When using this drug, careful monitoring of liver and kidney function is necessary, and caution is particularly required for the elderly or patients with heart disease. Rarely, this drug may cause various side effects such as allergic reactions, gastrointestinal disturbances, liver dysfunction, kidney problems, skin rashes, and central nervous system symptoms. If any abnormal symptoms appear, medical personnel should be notified immediately. To prevent the occurrence of resistant bacteria, it is essential to confirm the susceptibility of the causative bacteria and take this medication only for the required minimum duration. If symptoms such as diarrhea or abdominal pain become severe while taking, it may lead to serious intestinal conditions such as pseudomembranous colitis, and one should stop administration immediately and consult a healthcare provider. This drug may interact with various other medications, so it is important to consult a healthcare professional if taking other medications, especially when combining with antihypertensives, anticoagulants, steroids, antiepileptics, certain cardiac medications, etc. It is safest not to use this drug during pregnancy or breastfeeding, and if it is necessary to use it, breastfeeding should be suspended. Dosage adjustments or careful administration of this drug is required for children or the elderly, especially those with impaired kidney or liver function. In case of overdose, gastrointestinal disturbances or psychological symptoms may occur, and one should visit a medical facility immediately for appropriate treatment, as this drug cannot be removed by hemodialysis. When storing, it should be kept in a tightly sealed container that protects from light. Moreover, to maintain its effectiveness, it is important to store at room temperature, specifically between 15 and 30 degrees Celsius.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, hives, mild skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pan-cytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, paresthesia, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, increased total bilirubin, increased serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste disorder, hearing loss, paresthesia, arthralgia, myalgia, olfactory impairment, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized pustular psoriasis, muscle cramping, musculoskeletal rigidity, myopathy, increased serum creatinine, increased serum urea, nephritis, phlebitis at the injection site, pain at the injection site, inflammation at the injection site, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medication is sensitive to light, so it should be stored in a light-protected airtight container. Additionally, to maintain appropriate efficacy, it is important to store it at room temperature, specifically between 15 and 30 degrees Celsius.

Appearance

Yellow elliptical film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle, 200 tablets/bottle