Icozol Tablet (Itraconazole Solid Dispersion)

Adult dose

This medicine should preferably be administered immediately after a meal to increase absorption. 1. Short-term treatment This medicine continues to exert a therapeutic effect in skin tissue even after treatment is discontinued. Therefore, the final clinical and mycological response should preferably be assessed 2～4 weeks after completing the prescribed course of treatment. 1) Candida vaginitis: Administer itraconazole 200 mg per dose, 2 times daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Tinea versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis, tinea cruris (jock itch): Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital), tinea pedis (interdigital): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palm), tinea pedis (sole): Administer 100 mg once daily for 30 days or 200 mg per dose, 2 times daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis of the fingernails and toenails 1) Pulse therapy Administer 200 mg per dose, 2 times daily for 1 week, followed by a 3-week treatment-free period; this constitutes 1 cycle. Administer up to 2 cycles if only the fingernails are infected, and up to 3 cycles if the toenails are infected. Toenails (with or without concurrent fingernail infection): Treatment week 1, treatment-free weeks 2, treatment week 3, treatment-free week 4, treatment week 5 Fingernails: Treatment week 1, treatment-free weeks 2, treatment week 3 2) Continuous therapy Administer 200 mg once daily for 3 months. The therapeutic effect continues for 3 months for fingernails and 6 months for toenails after treatment ends. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplant recipients, oral bioavailability of this medicine may be reduced; if necessary, double the dose. Aspergillosis: 200mg once daily, 2～5 months. For invasive or disseminated disease, increase to 200mg per dose, 2 times daily Candidiasis: 100～200mg once daily, 3 weeks～7 months Cryptococcal meningitis: 200mg 2 times daily, 2 months～1 year. Maintenance therapy: 200mg once daily Paracoccidioidomycosis: 100mg once daily, 6 months

This medication should be used with caution in patients with impaired cardiac function, especially those with congestive heart failure, as it may lead to life-threatening situations. Patients with hypersensitivity to this drug or a history of impaired cardiac function should not use it. Additionally, there are many contraindicated drugs that may cause serious side effects or changes in drug efficacy when taken with this medication, so it is necessary to consult a physician or pharmacist before use. Women who are pregnant or may become pregnant, as well as breastfeeding women, should not take this medication and should use effective contraception post-administration. Patients with impaired liver or kidney function may be affected by the metabolism and excretion of this drug, requiring dose adjustments and regular monitoring. Serious side effects such as liver damage, cardiac issues, neurological disturbances, and allergic reactions may occur infrequently; if symptoms appear, they should notify medical personnel immediately. Furthermore, this medication may not be well absorbed in low acidity conditions, so taking it with acidic beverages may help. Side effects such as dizziness, visual disturbances, and hearing loss may occur, so caution is needed when driving or operating machinery. In the case of overdose, there is no specific antidote, and immediate hospital care should be sought. Finally, this medication should be kept out of reach of children, stored in its original container to prevent misuse or deterioration in quality.

headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory infection, leukopenia, hypersensitivity, taste disorder, sensory decline, sensory abnormality, tinnitus, constipation, diarrhea, dyspepsia, bloating, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, hives, frequent urination, erectile dysfunction, menstrual disorder, edema, granulocytopenia, thrombocytopenia, anaphylactoid reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, confusion, peripheral neuropathy, dizziness, drowsiness, tremors, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, voice disorders, cough, gastrointestinal disorders, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, kidney impairment, urinary incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, elevated alanine aminotransferase, elevated aspartate aminotransferase, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, elevated blood urea, increased gamma-glutamyltransferase, increased liver enzymes, abnormal urinalysis, increased white blood cells, increased eosinophils, anemia, vascular edema, serum sickness, vascular neurogenic edema, anaphylaxis, anaphylactic shock, allergic reaction, double vision, visual impairment, temporary hearing loss, permanent hearing loss, ventricular extra contractions, atrioventricular block, palpitations, increased intestinal motility, belching, glossitis, stomatitis, abdominal flank pain, pancreatitis, elevated serum total protein, elevated total bilirubin, elevated LAP, loss of appetite, malaise, jaundice, dark urine, increased liver enzyme levels, mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Riel syndrome, erythema multiforme, alopecia, photosensitivity reaction, exfoliative dermatitis, leukocyte destructive vasculitis, acute generalized exanthematous pustulosis, elevated BUN, positive urine protein test, positive urine glucose test, decreased libido, drowsiness, shoulder stiffness, insomnia, chest pain, elevated serum triglyceride levels, flushing, elevated serum uric acid levels, elevated serum potassium levels, serum sickness, vascular neurogenic edema, anaphylactic reaction, hypertriglyceridemia, tremors, blurred vision, congestive heart failure, dyspnea, significant hepatotoxicity, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, increased serum creatine phosphokinase

This drug should be stored in a sealed container to prevent air ingress, and it is recommended to keep it at room temperature between 1 to 30 degrees Celsius. This way, the efficacy of the medication can be maintained for a longer period.

Appearance

White or creamy yellow round film-coated tablet

Package unit

28 tablets/bottle, 100 tablets/bottle