Elpidogrel Tablets (Clopidogrel Sulfate)

Adult dose

For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, 75 mg of clopidogrel should be taken orally once daily. In acute coronary syndrome patients, a loading dose of 300 mg should be started once daily on the day of initiation, followed by a maintenance dose of 75 mg taken orally once daily. Aspirin at 75 to 325 mg should be co-administered once daily. For atrial fibrillation patients, 75 mg should be taken orally once daily.

This medication is an antiplatelet drug that prevents the aggregation of platelets in the blood, thereby preventing thrombosis. The effect of this medication is manifested after it is converted to an active form in the body, which involves a specific enzyme (CYP2C19). Therefore, people genetically deficient in the function of this enzyme may experience reduced efficacy of the drug, and alternative treatment methods should be considered in such cases. Taking this medication together with specific drugs (e.g., drugs that activate CYP2C19) can increase the concentration of this medication and heighten the risk of bleeding, so co-administration should be avoided. Patients with a high risk of bleeding, severe liver damage, lactose intolerance, or those who are nursing should not use this medication. Patients at risk of bleeding must be especially cautious when using this medication and should immediately inform healthcare personnel of any bleeding symptoms that appear. If surgery is planned, this medication should be discontinued 5 to 7 days before surgery and resumed after hemostasis is achieved. This medication increases the risk of bleeding when used with other bleeding risk medications (aspirin, non-steroidal anti-inflammatory drugs, anticoagulants, etc.), so caution is necessary. During the use of this medication, if bleeding symptoms, skin rashes, or signs of infection occur, the patient should immediately consult a physician. If pregnant or nursing, the decision to take this medication should be made after consulting a physician, especially due to the potential for bleeding risk before delivery. Elderly patients and those with impaired kidney or liver function require dosage adjustments and close monitoring while using this medication. In case of overdose, the risk of bleeding may increase significantly, so patients should adhere to the prescribed dosage and inform healthcare personnel immediately of any abnormal symptoms. This medication should be kept out of the reach of children, and transferring it to other containers should be avoided.

Serious side effects

Hives, severe swelling (edema), bleeding (gastrointestinal bleeding, intracranial bleeding, hematoma, hematuria, intraocular bleeding), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with high fever, blisters, peeling skin, pain in oral/ocular mucosa, severe allergic reactions, severe skin adverse reactions, respiratory problems, yellowing of the skin or eyes (jaundice), profound lethargy, liver problems (jaundice), sudden and severe

Mild side effects

• Chest pain
• accidental injury
• influenza-like illness
• pain
• fatigue
• headache
• dizziness
• abdominal pain
• indigestion
• diarrhea

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is best to maintain a storage temperature between 1°C and 30°C room temperature. Proper storage will help maintain the medication's effectiveness over time.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle