Expain ER Semi-Extended Release Tablet

Adult dose

The dosage should be adjusted based on the patient's level of pain and treatment response. An initial dose of 2 tablets is recommended, and subsequent doses should be spaced at least 12 hours apart, not exceeding 8 tablets per day. In cases where long-term administration is required, regular monitoring should be conducted to determine the need for continued treatment. Elderly patients should typically receive standard adult doses, but those over 75 years old should be administered at intervals of at least 12 hours.

This medication may put strain on the liver, so individuals who consume alcohol in amounts exceeding a certain limit daily should consult a doctor or pharmacist before taking it. Some ingredients in this medication may rarely cause serious skin reactions, so if you experience a rash or allergy symptoms, you should immediately stop taking the medication and consult a healthcare professional. The tramadol component in this medication may trigger seizures, thus patients with a history of seizures or those at high risk of seizures should take caution, especially when used with certain antidepressants or other medications, as this may increase the risk of seizures. Rarely, serious allergic reactions may occur while taking this medication, so immediate emergency treatment is necessary if symptoms such as difficulty breathing or facial swelling occur. In patients with acute and severe bronchial asthma, this medication may make breathing more difficult, therefore it should be administered carefully in an environment equipped with medical equipment. Combining this medication with alcohol or central nervous system depressants can lead to severe drowsiness, respiratory depression, and the risk of coma, so it should be avoided or used under strict medical supervision. Patients with head injuries or increased intracranial pressure may experience worsening of symptoms due to respiratory depression from this medication, so caution is advised. This medication can lead to psychological and physical dependence, so long-term users should be closely monitored for signs of dependency. The acetaminophen component in this medication can cause liver damage in case of overdose, so it is essential to avoid exceeding the daily dosage, and patients with poor liver function should consult a doctor before taking it. Patients with certain genetic traits may metabolize this medication quickly and have elevated blood levels, hence dosage adjustment or substitution with alternative medications may be necessary. Children, especially those under 12 years old or adolescents under 18 who have undergone tonsillectomy and adenoidectomy, should not be given this medication, and special caution should be taken for children aged 12 to 18 if there are risk factors. This medication may cause hyponatremia, or reduced sodium levels in the blood, hence it is advised to check blood levels periodically during treatment, especially in the elderly or those with risk factors. The side effects such as drowsiness and respiratory depression may increase when this medication is taken with other central nervous system depressants, so careful monitoring and possible dosage adjustment are necessary during combined use. The safety of this medication during pregnancy has not been established; thus it should only be used when the benefits outweigh the risks, as determined by a doctor, and it is advisable to avoid use during breastfeeding. Caution is advised when engaging in activities that require alertness, such as driving or operating machinery, as drowsiness or dizziness may occur after taking this medication. Overdose of this medication can lead to serious symptoms such as respiratory depression, coma, and liver damage; therefore if an overdose occurs, you should immediately visit a medical institution for appropriate treatment.

Serious side effects

Hives, severe swelling (angioedema), tightness in the chest, difficulty breathing, cold sweat, paleness, severe allergic reactions, severe rashes associated with high fever, blisters, skin peeling, mucosal pain in the mouth/eyes, severe skin abnormal reactions, difficulty breathing or shortness of breath, asthma attacks, cough + fever accompanied breathing abnormalities, respiratory problems, yellowing of the skin or eyes (jaundice), extreme lethargy, liver abnormalities (jaundice), sudden and

Mild side effects

• Weakness
• fatigue
• flushing
• stiffness
• fainting
• withdrawal symptoms
• hypertension
• exacerbation of hypertension
• hypotension
• arrhythmias

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is recommended to maintain room temperature between 1°C and 30°C.

Appearance

Pale yellow round film-coated extended release tablet

Package unit

30 tablets, 200 tablets/bottle