Amoctin Duo Syrup (Amoxicillin Monohydrate · Potassium Clavulanate (7:1))

Adult dose

For recurrent tonsillitis or other upper respiratory infections, lower respiratory infections, urinary tract infections, and mild to moderate skin and soft tissue infections, Amoxicillin/Clavulanate is typically taken at a dosage of 25 mg/3.6 mg per kg body weight split into two doses daily. In cases of severe infections such as otitis media, sinusitis, or lower respiratory infections like bronchopneumonia and urinary tract infections, the typical dosage of Amoxicillin/Clavulanate is 45 mg/6.4 mg per kg body weight split into two doses daily.

Child dose

The 7:1 syrup is not suitable for children under 2 months of age. The 7:1 syrup is not suitable for pediatric patients with renal impairment.

This medication is a beta-lactam antibiotic and should not be administered to patients with hypersensitivity reactions to penicillins or cephalosporins. Special caution is needed in cases with a history of severe allergic reactions such as anaphylaxis, Stevens-Johnson syndrome, and shock. Also, it should be avoided in patients with viral diseases like infectious mononucleosis or lymphocytic leukemia due to an increased risk of rashes. Patients with a history of liver function impairment or jaundice also require cautious use due to the risk of recurrence. Dosage and administration intervals should be adjusted for patients with liver impairment or moderate to severe renal impairment as drug concentration may increase. Allergy-prone individuals or the elderly should be monitored for bleeding tendencies due to possible vitamin K deficiency. Gastrointestinal side effects may include diarrhea, abdominal pain, nausea, and vomiting; if severe diarrhea or abdominal pain occurs, medication should be discontinued immediately. Liver dysfunction has also been reported, and liver function tests should be monitored regularly during or after treatment. Rarely, severe hypersensitivity reactions such as rashes, urticaria, angioedema, and anaphylactic shock may occur; in such cases, treatment should be stopped immediately and medical advice should be sought. Hematological abnormalities including leukopenia, thrombocytopenia, and anemia may arise, necessitating regular blood tests. Central nervous system symptoms such as anxiety, confusion, and seizures have also been rarely reported, especially in patients with renal impairment where renal adverse effects may occur. To prevent the emergence of resistant bacteria, the drug should be used for the minimum necessary duration during prolonged therapy, with regular checks of liver function, renal function, and hematologic function. Pregnant or nursing women should use this medication with caution, and it is advisable to avoid use, especially in the first three months of pregnancy. The elderly may experience adverse reactions due to decreased physiological functions and may have an increased tendency to bleed, thus requiring careful dosage adjustment and monitoring. This drug may interact with other medications; patients taking anticoagulants, anti-inflammatory agents, or oral contraceptives should inform their healthcare provider. In case of overdose, gastrointestinal symptoms, electrolyte imbalances, renal failure, and seizures may occur, necessitating immediate discontinuation and appropriate management. After preparation, this drug must be stored in the refrigerator and used within 7 days, and it should be shaken well before administration.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash with high fever, blisters, skin peeling, pain in oral/eye mucosa, severe skin adverse reactions, difficulty or trouble breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice, extreme lethargy, liver abnormalities, sudden, severe headache, thunderclap headache, seizures, altered consciousness.

Mild side effects

Diarrhea, membranous colitis, dyspepsia, stomatitis, gastritis, glossitis, nausea, vomiting, loss of appetite, abdominal pain, abdominal bloating, constipation, colic, acid reflux, soft stool, dry mouth, candidiasis, antibiotic-associated colitis, bloody stools, itching, erythema multiforme, mucocutaneous syndrome, toxic epidermal necrolysis, vesicular pemphigoid dermatitis, acute generalized exanthematous pustulosis, eosinophilia, angioedema, serum sickness syndrome, hypersensitivity vasculitis, acute generalized rash.

This medication must be stored in a tightly sealed container to avoid exposure to air and moisture. The appropriate storage temperature is in a cool place between 1 degree and 25 degrees.

Appearance

A syrupy preparation in a whitish powder form with a distinctive smell that is to be dissolved before use.

Package unit

50mL/bottle, 250mL/bottle