Aclan Tablet 375 mg

Adult dose

Adults and children aged 12 years and above or weighing 40 kg or more should take 250 mg of Amoxicillin / 125 mg of Clavulanate orally every 8 hours (3 times daily). In cases of severe or respiratory infections, the dosage can be increased to 500 mg of Amoxicillin / 125 mg of Clavulanate. In cases of renal impairment, the dosage should be adjusted according to creatinine clearance. - Creatinine clearance above 30 mL/min: No dosage adjustment needed.

Child dose

Children aged 12 years and above or weighing 40 kg or more should take the same dosage as adults. In cases of renal impairment, the dosage should be reduced as per adult guidelines.

This drug is a penicillin-class antibiotic and should not be administered to patients who have had hypersensitivity reactions to beta-lactam antibiotics. In particular, patients with a history of serious allergic reactions such as anaphylaxis, Stevens-Johnson syndrome, or shock should not use this medication. Additionally, it should be avoided in patients with infectious mononucleosis or lymphocytic leukemia due to a higher risk of rash. Patients with liver dysfunction or a history of jaundice should exercise caution as symptoms may recur. Caution is also necessary for patients with reduced liver function or moderate to severe renal impairment, as the drug may remain in the body longer, increasing the risk of side effects. Patients with allergic predisposition, those who have difficulty with oral intake, the elderly, and those in poor general condition may show vitamin K deficiency and bleeding tendencies. In cases of gastrointestinal diseases with severe vomiting or diarrhea, careful usage is necessary as drug absorption might be inadequate. If symptoms like diarrhea, abdominal pain, or blood in stool appear while taking this medication, administration should be stopped immediately and a physician consulted. Allergic reactions such as abnormal liver tests, skin rash, itching, and difficulty breathing may occur, and if these symptoms appear, medical personnel should be informed immediately. It's important to perform regular checks on liver function, kidney function, and blood tests during prolonged use. Women who are pregnant or breastfeeding should use this medication cautiously after consulting with their physician, as it may affect the fetus or infant. This drug is not recommended for children, especially those under 12 years of age or weighing less than 40 kg. The elderly may experience adverse reactions more easily due to diminished physiological functions, so dosage and administration intervals should be adjusted with careful observation. This drug may interact with other medications, so it's critical to inform healthcare providers about any medications being taken, particularly anticoagulants, anti-inflammatory drugs, and other antibiotics. In cases of overdose, gastrointestinal symptoms, renal failure, seizures, and hypersensitivity shock may occur, necessitating immediate discontinuation of the drug and emergency treatment. This medication should be stored in a dry place below 25 degrees Celsius, and it's important to adhere to the prescribed duration and dosage as directed by a physician.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe allergic reactions, severe rashes with high fever, blisters, skin peeling, pain in oral/ocular mucosa, severe cutaneous adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, liver abnormalities (jaundice), sudden and severe reactions

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain

This medication is kept in a tightly sealed container to prevent moisture and air from entering. Store it in a cool location between 1 to 25 degrees Celsius. Avoid direct sunlight and do not place it in excessively hot or cold areas.

Appearance

White or nearly white oval film-coated tablets

Package unit

80 tablets/box [(8 tablets/PTP*10)], 100 tablets/box [(10 tablets/PTP*10)]