Anasol Tablet (Methylprednisolone)

Adult dosage

The initial dose may vary from 4mg to 48mg of methylprednisolone per day, depending on the symptoms of the specific disease. In general, a low dose is sufficient for less severe conditions, but a high initial dose may be required in certain patients. The initial dose should be maintained or adjusted until a satisfactory response is achieved. The dose must be determined individually according to the various diseases being treated and the patient's response. After an adequate response is achieved, the appropriate maintenance dose should be determined by reducing the initial dose at suitable intervals until the lowest dose that maintains an adequate clinical response is reached. After long-term treatment, gradual dose reduction is recommended when discontinuing the medicine. For treatment of acute exacerbations of multiple sclerosis, daily administration of prednisolone 200mg for 1 week followed by administration of prednisolone 80mg every other day for 1 month is effective (methylprednisolone 4mg is equivalent to prednisolone 5mg). Alternate-day therapy means administering twice the daily dose on one morning out of every two days. Although a single morning dose causes considerably less adrenal suppression than taking prednisolone (10mg) in four divided doses every 6 hours, the initial suppressive dose should be continued until a satisfactory clinical response is obtained, usually for 4 to 10 days in many allergic and collagen diseases. Switch to ADT and gradually reduce the amount of corticosteroid given every other day. As disease progression is controlled, reduce the daily corticosteroid dose to the minimum effective dose as soon as possible, then switch to an alternate-day schedule. If this is difficult, it is preferable to administer three or even four times the daily dose every other day rather than simply doubling the daily dose. Once the patient is controlled again, attempt to reduce the dose to the lowest level. If an acute exacerbation occurs during disease progression, it may be necessary to return to a fully suppressive dose of corticosteroid divided throughout the day for control. Once controlled, the established alternate-day regimen may be attempted again.

This medication should not be administered to certain patients. For example, individuals allergic to this drug or any of its components, those with untreatable infections or systemic fungal infections, patients with herpes simplex, herpes zoster, chickenpox, individuals currently receiving live vaccines, and those with lactose intolerance or specific genetic metabolic disorders should not take it. Additionally, special caution is required when administering this medication to patients with specific conditions such as glaucoma, tuberculosis, posterior subcapsular cataracts, electrolyte imbalances, hypertension, thrombosis, recent bowel anastomosis, history of acute myocardial infarction, diverticulitis, peptic ulcers, psychosis, severe osteoporosis, diabetes, renal failure, congestive heart failure, hypothyroidism, fatty liver, fat embolism, severe myasthenia gravis, the elderly, and patients with ulcerative colitis. This medication can cause various side effects including edema, sodium retention, potassium loss, muscle weakness, osteoporosis, gastrointestinal disturbances, skin changes, psychiatric symptoms, endocrine disturbances, eye diseases, etc., so symptoms should be carefully monitored during administration. Long-term use may lead to adrenal insufficiency, and sudden discontinuation can be dangerous; therefore, dosage should be reduced gradually. During stress situations such as trauma, surgery, or infection, temporary dosage increases may be required. During treatment with this drug, immune function is suppressed, increasing the risk of infections, so care should be taken to avoid exposure to infectious diseases such as chickenpox or measles, and vaccination is also restricted. There may be interactions with multiple drugs, so if other medications are being taken, it is essential to consult with a doctor or pharmacist, especially regarding concomitant use with drugs that may cause cardiac arrhythmias, anticoagulants, blood glucose-lowering medications, diuretics, and antibiotics. Women who are pregnant or breastfeeding should consider the potential effects on the fetus or newborn, carefully weighing the benefits and risks of treatment, and it is recommended to discontinue breastfeeding. In children, side effects such as growth retardation may occur, so it should be administered with the minimum effective dose and growth should be monitored. For the elderly, there is a higher risk of side effects such as infections, diabetes, osteoporosis, hypertension, cataracts, and glaucoma, so special caution is necessary during administration. During the use of this medication, hypokalemia, skin reaction suppression, immune abnormalities, allergic reactions, and various adverse reactions may occur; therefore, if symptoms arise, immediate communication with healthcare professionals is required for appropriate action.

Edema, sodium retention, potassium loss, fluid retention, hypokalemic alkalosis, congestive heart failure, hypertension, myasthenia, aseptic necrosis of the femoral and humeral epiphysis, steroid myopathy, muscle wasting, pathologic fractures of the pelvis, osteoporosis, spinal compression fractures, arthralgia, tendon rupture, increased ALT, increased AST, increased ALP, nausea, thirst, vomiting, stomach pain, appetite loss, increased appetite, peptic ulcer, abdominal distension, pancreatitis, esophagitis, diarrhea, delayed wound healing, facial erythema, thin and fragile skin, abnormal sweating, petechiae, ecchymosis, inhibition of skin reactions, purpura, acne, hirsutism, hair loss, pigmentation, papilledema, increased intracranial pressure, seizures, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual irregularities, growth suppression in children, latent diabetes symptoms, secondary adrenal insufficiency, pituitary unresponsiveness, decreased glucose tolerance, increased requirement for insulin or oral hypoglycemic agents, inhibition of adrenocorticotropic hormone secretion, increased intraocular pressure, glaucoma, subcapsular cataract, secondary infections of the eye due to fungi or viruses, retinal disorders, exophthalmos, negative nitrogen balance due to catabolism, immune system disorders, allergic reactions, shock, urticaria, anaphylactic reactions, hypersensitivity reactions

This medication should be stored in a tightly closed container to protect it from air and moisture. The recommended storage temperature is room temperature between 1°C and 30°C. Proper storage will help maintain the efficacy of the drug for a longer period.

Appearance

White oval tablet

Package unit

30 tablets/bottle, 500 tablets/bottle