Rafudil Tablets (Rafutidine)

Adult dose

1. Short-term treatment of gastric ulcers: The usual dose is 10mg of lafutidine orally twice daily, in the morning and at bedtime. In clinical trials of up to 8 weeks, most ulcers healed within 8 weeks, although healing time may vary in some patients. 2. Short-term treatment of duodenal ulcers: The usual dose is 10mg of lafutidine orally twice daily, in the morning and at bedtime. In clinical trials of up to 6 weeks, most ulcers healed within 6 weeks, although healing time may vary in some patients. 3. Improvement of gastric mucosal lesions in acute and chronic gastritis: The usual dose is 10mg of lafutidine orally once daily at bedtime. In clinical trials of up to 2 weeks, most lesions healed within 2 weeks, although healing time may vary in some patients. 4. Combination therapy with antibiotics for patients with peptic ulcers infected with Helicobacter pylori: Administer lafutidine 20mg, clarithromycin 500mg, and amoxicillin 1000mg twice daily for 7 days or 14 days. 5. Premedication before anesthesia: The usual dose is 10mg of lafutidine per dose, given twice (at bedtime on the day before surgery and 2 hours before administration of anesthesia on the day of surgery). 6. Treatment of reflux esophagitis: Administer 10mg of lafutidine per dose orally twice daily.

This drug should not be used in patients with hypersensitivity to the ingredients. Furthermore, it contains lactose, so patients should avoid it if they have genetic problems such as lactose intolerance, deficiency of lactase, or glucose-galactose malabsorption. Patients with a history of hypersensitivity to medications, impaired liver or kidney function, dialysis patients, and the elderly should use this drug with caution. This drug can rarely cause severe allergic reactions such as anaphylaxis or shock, so if symptoms like shortness of breath, facial pallor, or low blood pressure occur, administration should be immediately discontinued and medical attention sought. Liver function abnormalities or jaundice may occur, so liver conditions should be monitored regularly, and if any abnormalities are found, medication should be discontinued. A decrease in blood cell count such as agranulocytosis or thrombocytopenia may occur, so if symptoms like sore throat, fever, or general malaise develop, immediate consultation with a doctor is recommended. Other reported side effects include constipation, diarrhea, hard stools, nausea, vomiting, abdominal bloating, loss of appetite, headache, insomnia, drowsiness, reversible confusion, hallucinations, altered consciousness, dizziness, chills, warmth, facial flushing, elevated white blood cell counts, increased eosinophils, decreased white blood cell counts, decreased red blood cell counts, decreased hematocrit, elevated ALT (GPT), elevated AST (GOT), elevated Al-P, elevated γ-GTP, elevated T-Bil, elevated LDH, increased TTT, abnormal urinary protein, BUN. In particular, if malignant tumors are suspected, this drug may alleviate symptoms and delay diagnosis, so if symptoms like weight loss, recurrent vomiting, or hematemesis occur, testing must be conducted. The elderly have decreased physical functions, so care must be taken regarding dosage and intervals, and they should be monitored closely during use. Dialysis patients may have elevated drug concentrations in the blood, so they should start with a lower dose initially. Pregnant women or women who may become pregnant should only take this under medical advice if the benefits outweigh the risks, and nursing mothers are advised against taking it as it may be excreted in breast milk. The safety in children has not been established, so its use is not recommended. This medication should be kept out of reach of children and stored in its original container; transferring it to another container poses a risk of misuse or degradation of quality.

• Shock
• symptoms of anaphylaxis
• facial pallor
• hypotension
• generalized rash
• dyspnea
• liver function impairment
• jaundice
• agranulocytosis
• pharyngitis

This medication must be stored in a tightly sealed container to avoid exposure to air or moisture. Additionally, it is important to store it at a cool room temperature between 1 to 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle