Famciclovir 250 mg Tablet

Adult dose

1. Treatment of herpes zoster infection Adults: Administer famciclovir 250 mg per dose orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer this medicine 250 mg per dose orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer this medicine 125 mg per dose orally twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this medicine 250 mg per dose orally twice daily. Interrupt treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: As creatinine clearance of this medicine is reduced in patients with renal impairment, dose adjustment should be undertaken with care. The dosage for these patients is as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 125 mg per dose twice daily 10～29 125 mg per dose once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance may be calculated using the following equations: Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients on hemodialysis, it is preferable to administer this medicine every 48 hours, taking the dialysis interval into account. Four hours of hemodialysis reduces the plasma concentration of this medicine by approximately 75%; therefore, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is required for patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This medication should not be used by patients who are allergic to specific components or have previously experienced hypersensitivity reactions. Patients with genetic disorders that prevent lactose digestion or those allergic to soybean oil, soybeans, peanuts, etc., should not take this drug. Caution is required for patients with impaired renal function or dyslipidemia, and their condition should be carefully monitored. Various side effects such as headache, dizziness, nausea, vomiting, and skin rashes may occur during treatment; if severe symptoms or abnormal reactions are suspected, immediate consultation with a healthcare professional is necessary. This medication cannot completely cure genital herpes; therefore, it is important to avoid sexual contact and maintain safe sexual relations if symptoms persist during treatment. Extra caution should be taken while driving or operating machinery if dizziness or drowsiness occurs, and these activities should be avoided if such symptoms are present. Patients with severely impaired liver function may experience decreased efficacy, so consultation with a healthcare professional prior to use is advised. Patients with other lipid-related diseases should regularly check their blood lipid levels and adjust their medication dosage if necessary. This medication may interact with various drugs, so it is essential to inform the healthcare professional about any other medications being taken. Pregnant or breastfeeding women should thoroughly consider the benefits and risks of using this medication and make a decision in consultation with their healthcare provider. It is generally recommended not to use this drug for children under 18, as safety and effectiveness have not been established. Elderly patients typically do not require dosage adjustments, but dosage may need to be adjusted in cases of impaired renal function. Overdosing may require appropriate treatment, and blood dialysis can be performed to reduce the drug concentration. This medication should be stored in a dry place below 30 degrees and kept out of reach of children. Additionally, transferring the drug to another container should be avoided as it might affect the quality of the medication.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is also advisable to store it in a cool, dry place below 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

21 tablets (7 tablets/PTP x 3)