Famciclovir Tablet 250 mg (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir 250 mg per dose orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of an initial episode of genital herpes Adults: Administer 250 mg of this medicine per dose orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes Adults: Administer 125 mg of this medicine per dose orally twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer 250 mg of this medicine per dose orally twice daily. Temporarily discontinue treatment at regular intervals every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Because the creatinine clearance of this medicine is reduced in patients with renal impairment, dose adjustment should be undertaken with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and an initial episode of genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 125 mg per dose twice daily 10～29 125 mg per dose once daily 3) Suppression of recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following formula. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients on hemodialysis, administration every 48 hours is preferable, taking the dialysis interval into account. Since 4 hours of hemodialysis reduces the plasma concentration of this medicine by approximately 75%, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, a clear recommended dose has not been established.

This medication should not be used in patients with specific allergic reactions or those sensitive to lactose, which is one of the ingredients. It should not be administered to patients with lactose intolerance or metabolic disorders. Patients with compromised kidney function need to be cautious when using this medication, and dosage adjustments may be required. During treatment with this medication, symptoms such as headache, nausea, and dizziness may occur, but they are mostly mild to moderate. Rarely, side effects such as decreased blood cell count, liver function abnormalities, and skin rashes may occur, so if any unusual symptoms arise, consultation with a physician is necessary. This medication does not cure genital herpes, so it is essential to avoid sexual contact when symptoms are present and maintain safe sexual practices. If dizziness or drowsiness occurs, driving or operating machinery should be avoided. Generally, elderly patients do not require dosage adjustments, but adjustments may be necessary if kidney function is impaired. In case of overdose, appropriate treatment is needed, and blood dialysis can be used to reduce drug concentration. This medication should be stored in a dry place below 30 degrees Celsius and kept out of reach of children. Additionally, transporting it to another container may adversely affect its quality, so care must be taken.

• Headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication may be sensitive to air or moisture, so it must be stored in a tightly closed container. It should also be kept in a cool and dry place below 30 degrees Celsius to maintain its effectiveness.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle