Bearyl M Tablet 2/500mg (Glibenclamide, Metformin Hydrochloride)

Adult dose

This medication is administered 1-2 times a day before meals or with meals. The dosage can be adjusted considering the patient’s current treatment regimen, efficacy, and tolerability, with appropriate blood sugar monitoring. Treatment usually begins at a low dose, and the dosage can be adjusted based on the patient’s current medications and blood sugar levels. In clinical trials, the initial daily dosage was Glibenclamide/Metformin Hydrochloride 2mg/

This medication can cause severe lactic acidosis or hypoglycemia, so it should be discontinued if renal function rapidly declines. It is important to temporarily stop taking this medication and consult a doctor if there are symptoms of dehydration. Caution should be exercised when taking this medication together with other drugs that can cause acute renal failure. Excessive alcohol consumption, liver dysfunction, and poorly controlled diabetes can also increase the risk of side effects with this medication. Patients and caregivers must be thoroughly educated about the risks and symptoms of lactic acidosis, and if symptoms occur, they should immediately stop taking the medication and seek emergency care. Renal function should be evaluated before starting treatment and regularly thereafter; this medication is not used in patients with reduced kidney function. This medication should not be administered to patients with insulin-dependent diabetes, acute metabolic acidosis, severe liver dysfunction, pregnant or breastfeeding women, or those with severe kidney impairment. Patients at high risk for hypoglycemia, those in a state of malnutrition, elderly patients, and patients with liver dysfunction should use this medication with caution and carefully monitor for symptoms of hypoglycemia. This medication may cause gastrointestinal disturbances, allergic reactions, hematological abnormalities, vitamin B12 deficiency, and other side effects, so consult a doctor immediately if abnormal symptoms occur. Regularly check blood sugar control status and be cautious about potential interactions with other medications. In particular, when used in combination with drugs that affect renal function, kidney function should be monitored, and treatment should be temporarily suspended in cases of acute illness or surgery. Patients who are pregnant or planning to become pregnant should switch to insulin therapy instead of this medication, and breastfeeding women should avoid administration as well. Dosing and administration for children and elderly individuals should be determined cautiously, with special attention to reduced kidney function in the elderly. In case of overdose, hypoglycemia or lactic acidosis may occur, so inform medical personnel immediately and receive appropriate treatment. While taking this medication, it is important to maintain a regular diet and exercise regimen, as well as consistently perform blood sugar and kidney function tests. Special care is needed while driving or operating machinery due to the risk of accidents from hypoglycemia or hyperglycemia. Keep this medication out of reach of children and do not transfer it to another container.

Serious side effects

Hives, severe swelling (edema), cardiac arrest, headaches, seizures, confusion, visual disturbances, paralysis, platelet count below 10,000/μL and thrombocytopenic purpura, yellowing of the skin or eyes (jaundice), liver failure, lactic acidosis, severe hypoglycemia, difficulty breathing, respiratory distress, asthma attacks, breathing difficulties accompanied by coughing and fever, markedly reduced urine output, severe systemic edema, elevated blood pressure

Mild side effects

• Nausea
• vomiting
• abdominal distension
• loss of appetite
• indigestion
• constipation
• abdominal pain
• taste disorders
• thrombocytopenia
• leukopenia

This medication should be stored in a tightly sealed container to prevent air and moisture from entering. The appropriate storage temperature is between 1 to 30 degrees Celsius at room temperature. By storing this medication in this manner, its effectiveness can be maintained for a long time.

Appearance

White oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle