Huons Itraconazole Tablets (Itraconazole Solid Dispersion)

Adult dose

It is preferable to administer this drug immediately after a meal. 1. Short-term treatment The final clinical and mycological response should preferably be assessed 2～4 weeks after completion of the prescribed treatment. 1) Vulvovaginal candidiasis: Administer itraconazole 200 mg twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Pityriasis versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis, tinea cruris: Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital type), tinea pedis (interdigital type): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palmar), tinea pedis (plantar): Administer 100 mg once daily for 30 days or 200 mg twice daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200 mg twice daily for 1 week, followed by 3 weeks without treatment; this constitutes one cycle. Treat for up to 2 cycles for fingernail infection only and up to 3 cycles for toenail infection. Toenails (with or without concomitant fingernail infection): Week 1 treatment, Week 2 no treatment, Week 3 treatment, Week 4 no treatment, Week 5 treatment Fingernails: Week 1 treatment, Week 2 no treatment, Week 3 treatment 2) Continuous therapy Administer 200 mg once daily for 3 months. The treatment effect continues for 3 months for fingernails and 6 months for toenails after treatment is completed. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplant recipients, oral bioavailability of this drug may be reduced; if necessary, double the dose. Aspergillosis: 200mg once daily, average treatment duration 2～5 months. For invasive or disseminated disease, increase to 200mg twice daily Candidiasis: 100～200mg once daily, average treatment duration 3 weeks～7 months Cryptococcal meningitis: 200mg twice daily, average treatment duration 2 months～1 year. Maintenance therapy: 200mg once daily Paracoccidioidomycosis: 100mg once daily, average treatment duration 6 months

This medication should not be used in patients with impaired heart function. It is especially important to avoid administering it to patients with congestive heart failure or a history of cardiac dysfunction unless the infection is life-threatening. If symptoms of cardiac problems occur while taking this medication, it is important to stop administration immediately and consult a physician, as this medication may decrease the contractility of the heart muscle. Persons with allergies to this medication or its components should not take it under any circumstances. This medication has many drug interactions, so caution is warranted, especially when used in combination with heart-related medications, analgesics, anticoagulants, antipsychotics, or anticancer agents. Therefore, it is essential to inform healthcare providers of all medications being taken, and to avoid taking contraindicated medications. Women who are pregnant or may become pregnant, as well as those who are breastfeeding, should not take this medication, as it may affect the fetus and can be transmitted through breast milk. Patients with liver or kidney dysfunction may need dose adjustments while using this medication and should have regular liver function tests. Caution is needed due to the risk of hepatotoxicity or kidney issues. During treatment with this medication, side effects such as dizziness, headaches, dyspepsia, nausea, rashes, etc. may occur, and any severe adverse symptoms should be reported to healthcare professionals immediately. This medication is not well absorbed in low acidic conditions; therefore, taking it with acidic beverages may help when combined with medications that decrease stomach acidity. Caution is needed when driving or operating machinery as dizziness or visual disturbances may occur. In case of overdose, there is no specific antidote; thus, recommended dosages should be strictly followed, and it should be kept out of reach of children. It is crucial to discuss personal health conditions and current medications with healthcare providers before and during the use of this medication, and to have regular check-ups to use it safely.

Headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory infection, leukopenia, hypersensitivity, taste disorder, sensory loss, sensory abnormality, tinnitus, constipation, diarrhea, dyspepsia, bloating, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, urticaria, polyuria, erectile dysfunction, menstrual disorders, edema, granulocytopenia, thrombocytopenia, anaphylactic-like reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, confusion, peripheral neuropathy, dizziness, drowsiness, tremors, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, speech disorders, cough, gastrointestinal disorders, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, kidney disorders, urinary incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, leukocytosis, eosinophilia, anemia, vascular edema, serum sickness, angioedema, anaphylaxis, anaphylactic shock, allergic reaction, double vision, visual impairment, hearing loss, ventricular ectopic beats, atrioventricular block, palpitations, increased intestinal motility, belching, glossitis, stomatitis, abdominal and lumbar pain, pancreatitis, elevated serum total protein, elevated total bilirubin, elevated LAP, loss of appetite, malaise, dark urine, increased liver enzymes, mucosal erythema syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Riel syndrome, erythema multiforme, hair loss, photosensitivity reactions, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized pustular exanthema, elevated BUN, positive urine protein test, positive urine glucose test, decreased libido, drowsiness, shoulder stiffness, insomnia, chest pain, elevated serum triglycerides, warmth sensation, elevated serum uric acid, elevated serum potassium, serum sickness, angioedema, anaphylactic reaction, hypertriglyceridemia, tremors, visual impairment, hearing loss, congestive heart failure, dyspnea, pancreatitis, severe hepatotoxicity, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized pustular exanthema, erythema multiforme, exfoliative dermatitis, leukocytoclastic vasculitis, hair loss, photosensitivity, increased serum creatine phosphokinase levels

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. Additionally, it is safe to keep it at room temperature, between 1°C and 30°C, away from excessively hot or cold places.

Appearance

Round film-coated tablets that are white or pale yellow

Package unit

30 tablets/bottle, 100 tablets/bottle