Apomin Tablets (Metformin Hydrochloride)

Adult dose

The dosage should be determined individually based on drug efficacy and tolerance, and should not exceed the recommended maximum dosage per day. Dosing should start at a lower dosage, typically 500 mg taken 2-3 times daily with meals. Dosage increases should be made gradually by 500 mg weekly, and doses up to 2000 mg should generally be divided and taken twice daily in the morning and evening. If doses exceed 2000 mg, they should be taken 3 times daily.

Child dose

Can be used in children over 10 years or adolescents in growth. The typical starting dosage is 500 mg once daily, taken during or after meals. After a week, blood sugar levels should be measured to adjust the dosage.

This medication should not be administered to patients with impaired kidney function. Serious side effects like lactic acidosis may occur if kidney function is moderately or severely impaired. This medication should not be used in patients with acute conditions such as acute infections, heart failure, or myocardial infarction. In such states, the risk may increase due to worsened kidney function. Patients who are scheduled to undergo examinations using iodine-based contrast agents should temporarily discontinue this medication for a certain period before and after the exam, and resume it only after confirming normal kidney function. This medication is not administered to patients who have had allergic reactions to it, patients with type 1 diabetes, or those with diabetic ketoacidosis. Patients with severe infections, significant trauma, or those undergoing surgery should temporarily stop taking this medication, and can resume it only after their condition has stabilized and kidney function is confirmed to be normal. Patients with poor nutritional status or those with decreased liver function, and patients who consume excessive alcohol should use this medication cautiously. Liver impairment may increase the risk of lactic acidosis. This medication can lead to a rare but life-threatening side effect called lactic acidosis, so patients and caregivers should immediately inform their doctor if symptoms of lactic acidosis such as muscle pain, difficulty breathing, fatigue, or abdominal pain occur. Gastrointestinal symptoms (diarrhea, nausea, vomiting, etc.) may occur initially, but they are usually temporary and improve over time. Taking the medication slowly and with meals can reduce symptoms. While this medication lowers blood sugar, it rarely causes hypoglycemia on its own. However, caution is needed as hypoglycemia may occur when taken with other hypoglycemic agents, when meals are skipped, or during intense exercise. Regular monitoring of kidney function, blood sugar, and vitamin B12 levels is recommended to ensure there are no issues. Particularly, elderly patients and those with decreased kidney function require more frequent monitoring. This medication may be used during pregnancy only under special circumstances and with a physician's judgment, but should not be used in pregnant women at risk of placental insufficiency or preeclampsia. If breastfeeding, a discussion with a doctor is necessary regarding whether to continue breastfeeding or to discontinue medication, as this medication can pass into breast milk. This medication may interact with other drugs, so it is essential to inform the doctor or pharmacist of any other medications being taken, and to closely monitor blood sugar and the patient’s condition. In case of overdose, the medication can be removed via hemodialysis, so if overdose is suspected, immediate medical attention is necessary. This medication should be stored out of reach of children, and it is advised to avoid transferring it to another container, as it can negatively affect the quality.

Serious side effects

Lactic acidosis, severe lactic acidosis or hypoglycemia, severe allergic reactions (hives, severe swelling), severe skin reactions (rash with fever, blisters, skin peeling, mucosal pain), respiratory issues (difficulty breathing, asthma attacks, cough accompanied by fever and respiratory abnormalities), liver abnormalities (jaundice, yellowing of the skin or eyes, generalized malaise), serious neurological symptoms (sudden and severe headache, thunderclap headache, seizures, altered consciousness,

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, loss of appetite, indigestion, constipation, abdominal pain), unpleasant or metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver dysfunction, hypoglycemia (rarely severe delayed hypoglycemia)

This medication should be stored in a tightly closed container to prevent exposure to air and moisture. It is recommended to store it at room temperature between 1 and 30 degrees Celsius.

Appearance

White round film-coated tablets

Package unit

100 tablets/bottle, 500 tablets/bottle