Zalysid Tablets (Clarithromycin)

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medicine to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: For 14 days, administer 500mg (potency) of this medicine 3 times daily in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

○ Children aged 12 years and older: Same as adults ○ For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be administered to patients with certain medications or health conditions. For example, patients allergic to any component of this medication, those with specific heart diseases, and patients with severe liver or kidney dysfunction may be at risk if they use this medication. It is also advisable for pregnant or breastfeeding women to refrain from taking this medication. Caution is advised when using this medication in patients with reduced liver or kidney function, those with heart conditions, and elderly patients. This medication can rarely cause serious allergic reactions, skin rashes, liver dysfunction, gastrointestinal disorders, kidney abnormalities, neurological issues, and other side effects, so if any abnormal symptoms occur, it is essential to stop taking it immediately and consult a physician. When taken with other medications, interactions may lead to increased drug concentration or higher risk of side effects, so it is crucial to inform about any other medications being taken. Particularly, medications that may affect heart rhythm, those impacting liver or kidney function, anticoagulants, and certain antiviral medications should be avoided or used with caution. Regular monitoring of liver, kidney, and blood tests is crucial during treatment with this drug. Overdose may result in gastrointestinal disturbances or central nervous system symptoms, so it is important to strictly adhere to the prescribed dosage and immediately contact a medical institution in case of overdose. This medication should be taken exactly as instructed by a physician to prevent the emergence of antibiotic-resistant bacteria, and it should not be stopped or increased arbitrarily. Additionally, it should not be used in patients who cannot digest lactose due to specific genetic issues. Lastly, caution is needed as dizziness or confusion may occur while driving or operating machinery.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, skin erythema, angioedema, arthralgia, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient dental discoloration, pancreatitis, increased amylase, taste disorders, appetite loss, constipation, stool discoloration, membrane colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, tremors, numbness, behavior change, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorder, hypoglycemia, tinnitus, auditory impairment, purpuric rash, acute generalized pustular dermatitis (AGEP), muscle spasms, musculoskeletal rigidity, myopathy, elevated blood urea, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio (INR), prolonged prothrombin time, abnormal urine color, vasodilation, cardiac arrest, atrial fibrillation, premature beats, palpitations, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura

This medication should be stored in a dry place to prevent moisture. It should also be kept in a sealed container to avoid exposure to air and light. The recommended storage temperature is between 1°C and 30°C at room temperature.

Appearance

Yellow, oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle