Pharmacylidine Tablets (Procyclidine Hydrochloride)

Adult dose

1. Parkinson's disease The optimal dose varies by patient; determine the dosage and administration accordingly. Young adult patients and patients with postencephalitic Parkinson's disease may require higher doses than elderly patients and patients with arteriosclerotic Parkinson's disease. 1) Patients not receiving other drug therapy: Initially, administer procyclidine hydrochloride 2.5 mg orally 3 times daily after meals. If the patient tolerates it well, gradually increase to 5 mg per dose 3 times daily, or administer 5 mg only with the last dose. In some cases, a lower dose may provide a better therapeutic effect. If patients sometimes have difficulty adhering to bedtime dosing, it is preferable to omit the bedtime dose and divide the daily dose evenly during the day. To minimize adverse reactions, take this medicine during or after meals. 2) Switching from another drug therapy to procyclidine hydrochloride therapy In patients who have been continuously receiving another medicine, gradually switch all or part of the other medicine to this medicine at a dose of 2.5 mg per dose 3 times daily. Gradually increase the dose of this medicine as needed while correspondingly reducing or discontinuing the other medicine until the switch is complete. 2. Extrapyramidal symptoms caused by antipsychotics (phenothiazines, reserpine, etc.) When treating extrapyramidal symptoms caused by antipsychotics during treatment of psychiatric patients, adjust the dose according to the severity of adverse reactions associated with the antipsychotic. In general, the higher the antipsychotic dose, the more severe symptoms such as rigidity and tremor. Therefore, adjust the dose to meet each patient's needs and minimize symptoms as much as possible. To establish the daily dose of this medicine, start with 2.5 mg per dose 3 times daily and increase by up to 2.5 mg per day until symptoms improve. In most cases, 10～20 mg per day of this medicine provides a good effect.

This medication should not be used in certain patients. For example, those allergic to this drug or its components, patients with angle-closure glaucoma, untreated urinary retention or obstructive uropathy, patients with gastrointestinal obstruction, patients with severe myasthenia gravis, patients with severe ulcerative colitis, patients with delayed dyskinesia, those showing initial symptoms of dementia or demented patients, patients with intestinal atony, patients intoxicated with alcohol or certain drugs, and those with genetically related lactose intolerance should not take this medication. Additionally, caution should be exercised in patients with cardiovascular diseases, impaired liver or kidney function, patients with tachycardia symptoms, elderly patients, or patients with mental confusion or hallucinations. This drug is metabolized in the liver and excreted through the kidneys, so special caution is needed for those with weakened liver or kidney function. Side effects such as dry mouth, pupil dilation, blurred vision, dizziness, nausea, vomiting, constipation may occur while taking this medication. Patients may feel anxious or irritable and may occasionally experience hallucinations or confusion. Other symptoms such as skin rash, reduced sweating, urinary retention, palpitations, orthostatic hypotension may also occur, so caution is necessary. While taking this medication, it is advisable to avoid driving or operating machinery. Also, if taking with neuroleptics, tardive dyskinesia symptoms may worsen, so medication adjustment under a doctor's direction is necessary. Sudden discontinuation may cause Parkinson's symptoms to reappear, so doses should be tapered gradually. This medication may enhance the central nervous system depressant effects when taken with alcohol or other CNS depressants, so caution is needed. Additionally, there may be interactions with other medications, so it is essential to inform about any other medications being taken. Women who are pregnant or may become pregnant should carefully consider the risks and benefits before taking this medication, and breastfeeding is recommended to be discontinued during treatment. The safety in pediatric use has not been established, so it should only be used in special cases, and elderly patients are more sensitive to the medication, so starting with a lower dose and careful dose adjustment is suggested. In case of overdose, symptoms like tachycardia, flushing, dry skin, pupil dilation, confusion, hallucinations, urinary retention, and high fever may occur due to severe anticholinergic actions, so immediate medical attention is required. Lastly, this medication should be stored out of reach of children and transferring to another container is not desirable for maintaining quality and safety.

dry lips

This medication should be stored in a sealed container to prevent air exposure and is best kept at room temperature between 1°C and 30°C. Proper storage helps maintain the drug's effectiveness.

Appearance

Pale blue oval tablets

Package unit

30 tablets/bottle, 200 tablets/bottle