Medication info

Kwangdong Clarithromycin Tablet 250mg

Prescription medicationExpired
Ingredient · strength
Clarithromycin›Strength being verified
Manufacturer / importer
Kwangdong Pharmaceutical Co., Ltd.
Appearance
Yellow oblong film-coated tablet
Packaging
30 tablets/bottle, 100 tablets/bottle
Approval status
Expired

MFDS item code 201209006 · Approved 2012.11.30

This product's status changed to Expired on 2023.04.01. It may no longer be sold, so consult a doctor or pharmacist before taking it.

Summary

Main use
Treatment of respiratory and skin infections, mycobacterial infections, and Helicobacter pylori eradication
Who uses it
Adults · Children
Adult dosage
○ Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The treatment period is usually 7~14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer this medicine to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1~14), and omeprazole 40mg once daily for 28 days (days 1~28).
Children's dosage
Children 12 years and older: Same as adults Children under 12 years: Use clarithromycin dry syrup.

Ingredients

Manufacturer
Kwangdong Pharmaceutical Co., Ltd.

Efficacy & effects

Treatment of respiratory and skin infections, mycobacterial infections, and Helicobacter pylori eradication

  • Bronchitis
  • pneumonia
  • pharyngitis
  • sinusitis
  • skin and skin tissue infections
  • mycobacterial infections
  • duodenal ulcers.
View approved original text

This medication is used for lower respiratory tract infections such as bronchitis and pneumonia, as well as upper respiratory tract infections including pharyngitis and sinusitis, and is effective for the treatment of skin and skin tissue infections. It also helps in treating mycobacterial infections caused by Mycobacterium avium and Mycobacterium intracellulare. This drug is used for eradicating Helicobacter pylori in patients with duodenal ulcers. It is widely used for the treatment of infections caused by various bacteria, thus aiding in the improvement of infections.

Dosage and Administration

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The treatment period is usually 7~14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer this medicine to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1~14), and omeprazole 40mg once daily for 28 days (days 1~28).

Children's dosage

Children 12 years and older: Same as adults Children under 12 years: Use clarithromycin dry syrup.

Precautions

This medication should not be administered to patients who are allergic to certain excipients. Patients with a history of allergy to clarithromycin or similar class antibiotics should not use this medication. It may cause cardiac arrhythmias when taken with certain heart-related medications, so concurrent use should be avoided. Patients with significant cardiac arrhythmias or severely impaired liver function may be at risk if they take this medication. Patients with severely reduced kidney function should avoid certain formulations of this medication. Pregnant or lactating women should not take this medication, and if unavoidable, must discontinue breastfeeding. Administration should also be avoided in patients with central nervous system infections. This medication contains lactose, so patients with lactose intolerance should not take it. Dosing adjustments are necessary for patients with liver or kidney impairment, and those with heart disease should be particularly careful. Elderly patients or those on other antibiotics should also use this medication cautiously. Rarely, serious allergic reactions or skin rashes, liver function abnormalities, gastrointestinal disorders, kidney abnormalities, or central nervous system symptoms may occur; in such cases, the medication should be discontinued immediately and a doctor consulted. To prevent antibiotic resistance, it is important to take this medication only for the necessary duration. If diarrhea persists or abdominal pain worsens, it may indicate a serious condition such as pseudomembranous colitis, so medical personnel should be notified immediately. There are many drug interactions, so it's essential to inform healthcare providers of any concurrent medications, especially heart-related medications, anticoagulants, and hypoglycemic agents. Caution should be exercised when driving or operating machinery as dizziness or confusion may occur. Overdose may lead to gastrointestinal disturbances or mental symptoms, and in such cases, immediate medical treatment is required. This medication must be stored under proper conditions, and special care is needed when taken by children, elderly, or patients with weak liver or kidney function.

Side effects

  • Shock
  • anaphylactic symptoms
  • breathing difficulties
  • spasms
  • flushing
  • rash
  • itching
  • hives
  • skin flushing
  • angioedema
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  • joint swelling
  • drug rash
  • abdominal distension
  • nausea
  • vomiting
  • dyspepsia
  • abdominal pain
  • discomfort
  • flatulence
  • diarrhea
  • oral mucosal erosion
  • upper abdominal pain
  • thirst
  • transient dental discoloration
  • pancreatitis
  • increased amylase
  • taste abnormality
  • loss of appetite
  • constipation
  • discoloration of stool
  • pseudomembranous colitis
  • hemorrhagic colitis
  • abdominal pain
  • frequent diarrhea
  • fever
  • cough
  • abnormal chest X-ray
  • eosinophilia
  • eosinophilic pulmonary infiltrate
  • interstitial pneumonia
  • chronic bronchitis
  • acute maxillary sinusitis
  • eosinophilia
  • thrombocytopenia
  • pancytopenia
  • hemolytic anemia
  • leukopenia
  • agranulocytosis
  • dizziness
  • depression
  • loss of taste
  • loss of smell
  • anxiety
  • insomnia
  • nightmares
  • tinnitus
  • confusion
  • disorientation
  • hallucinations
  • psychosis
  • depersonalization
  • spasms
  • tremors
  • numbness
  • behavioral changes
  • manic behavior
  • Stevens-Johnson syndrome
  • toxic epidermal necrolysis
  • allergic purpura
  • drug rash
  • jaundice
  • hepatocellular hepatitis
  • cholestatic hepatitis
  • increased liver enzymes
  • liver dysfunction
  • liver failure
  • fulminant hepatitis
  • elevated AST
  • elevated ALT
  • elevated γ-GTP
  • elevated LDH
  • elevated ALP
  • increased total bilirubin
  • loss of appetite
  • dark urine
  • itching
  • abdominal tenderness
  • elevated serum creatinine
  • elevated BUN
  • interstitial nephritis
  • kidney failure
  • rhabdomyolysis
  • myalgia
  • weakness
  • elevated CPK
  • elevated serum myoglobin
  • elevated urinary myoglobin
  • glossitis
  • stomatitis
  • oral candidiasis
  • QT prolongation
  • ventricular tachycardia
  • Torsades de pointes
  • lethargy
  • headache
  • taste disturbance
  • hearing loss
  • paresthesia
  • arthralgia
  • myalgia
  • olfactory impairment
  • tinnitus
  • hearing impairment
  • hypoglycemia
  • tinnitus
  • hearing loss
  • vomiting
  • nausea
  • abdominal pain
  • purpuric rash
  • acute generalized eruptive pustulosis
  • soft tissue infection
  • candidiasis
  • gastroenteritis
  • vaginitis
  • pseudomembranous colitis
  • impetigo
  • superficial soft tissue infection
  • erythema nodosum
  • leukopenia
  • neutropenia
  • thrombocytosis
  • eosinophilia
  • agranulocytosis
  • thrombocytopenia
  • anaphylactic reaction
  • hypersensitivity
  • loss of appetite
  • decreased appetite
  • hypoglycemia
  • insomnia
  • anxiety
  • irritability
  • noise sensitivity
  • psychotic disorder
  • confusional state
  • depersonalization
  • depression
  • disorientation
  • hallucinations
  • abnormal dreams
  • mania
  • taste abnormality
  • headache
  • loss of consciousness
  • movement disorders
  • non-vertiginous dizziness
  • drowsiness
  • tremor
  • spasms
  • loss of taste
  • abnormal olfaction
  • loss of smell
  • vertiginous dizziness
  • hearing impairment
  • hearing loss
  • cardiac arrest
  • atrial fibrillation
  • ECG QT prolongation
  • premature contractions
  • palpitations
  • vasodilation
  • asthma
  • nosebleed
  • pulmonary embolism
  • diarrhea
  • vomiting
  • dyspepsia
  • nausea
  • abdominal pain
  • esophagitis
  • gastroesophageal reflux disease
  • gastritis
  • rectal pain
  • stomatitis
  • glossitis
  • abdominal distension
  • constipation
  • thirst
  • belching
  • flatulence
  • acute pancreatitis
  • tongue discoloration
  • dental discoloration
  • abnormal liver function tests
  • cholestasis
  • hepatitis
  • increased alanine aminotransferase
  • increased aspartate aminotransferase
  • increased gamma-glutamyltransferase
  • liver failure
  • hepatocellular jaundice
  • rash
  • sweating
  • vesicular dermatitis
  • itching
  • hives
  • papulovesicular rash
  • acne
  • Henoch-Schonlein purpura
  • muscle spasm
  • musculoskeletal rigidity
  • myalgia
  • rhabdomyolysis
  • myopathy
  • elevated serum creatinine
  • elevated blood urea nitrogen
  • kidney failure
  • nephritis
  • injection site phlebitis
  • injection site pain
  • injection site inflammation
  • lethargy
  • fever
  • weakness
  • chest pain
  • chills
  • fatigue
  • abnormal albumin-globulin ratio
  • elevated serum alkaline phosphatase
  • elevated serum lactate dehydrogenase
  • increased international normalized ratio
  • prolonged prothrombin time
  • urinary discoloration

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a dry place to prevent moisture and kept in a tightly sealed container to prevent air exposure. It should also be kept in a dark place, away from light, and at a temperature between 1 degree and 30 degrees Celsius.

Appearance and packaging

Appearance

Yellow oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.