Actovab 20 mg (Atorvastatin Calcium Hydrate)

Adult dose

For the treatment of hyperlipidemia, the recommended initial dose is 10 mg of atorvastatin once daily, and for those requiring greater reductions in LDL cholesterol levels, it can be started at 20 mg or 40 mg once daily. Dosing should be tailored within the range of 10 to 80 mg once daily, based on treatment goals and patient characteristics. Lipid levels should be assessed and dose adjustments made within 2-4 weeks of starting treatment and after any adjustments. The goal of treatment is to lower LDL cholesterol levels; it is recommended to use LDL cholesterol levels to assess treatment initiation and response. However, if LDL cholesterol levels cannot be obtained, total cholesterol levels may be used to monitor treatment response. In patients with homozygous familial hypercholesterolemia, the dosing regimen is 10 to 80 mg once daily, administered in conjunction with other lipid-lowering therapies (e.g., LDL apheresis) or if such therapies are not possible. For pediatric patients with heterozygous familial hypercholesterolemia (ages 10-17), the recommended initial dose is 10 mg once daily, and the recommended maximum dose is 20 mg once daily (there is no clinical data for doses higher than 20 mg in this pediatric population). Dose adjustments should be made accordingly based on the recommended treatment goals, with at least a 4-week interval between adjustments. ○ In patients with renal impairment: Renal disease does not affect the plasma concentration or LDL cholesterol-lowering effect of atorvastatin, hence dose adjustments are not necessary. ○ In the elderly: The efficacy and safety in patients aged 70 years and older are similar to those in adult patients.

Child dose

The recommended initial dose for pediatric patients with heterozygous familial hypercholesterolemia (ages 10-17) is 10 mg once daily, with a maximum dose of 20 mg once daily. Dose adjustments should be made according to the recommended treatment goals, having at least a 4-week interval between adjustments.

This medication may pose a risk of muscle problems, so if there is severe muscle pain or weakness, or significant increases in muscle-related tests, the medication should be discontinued immediately. This drug should not be used in patients with severely impaired liver function, muscle diseases, pregnant or breastfeeding women, or children under 10 years of age. Patients with a history of liver disease or alcoholism, those with weakened kidney function, patients with hypothyroidism, and the elderly should use this medication with extra caution and undergo regular muscle and liver function tests. Although this medication is generally well tolerated, occasionally symptoms such as dyspepsia, headache, myalgia, abnormal liver function, and allergic reactions may occur. If these symptoms are severe, consulting a physician is recommended. Regular liver function tests should be conducted during the course of this medication, and if symptoms such as nausea, fatigue, or jaundice appear, the doctor should be notified immediately. This medication can increase blood concentration and risk of side effects when taken with certain drugs, so if other medications are being taken, it is essential to inform a physician or pharmacist. Particular caution is needed when taken with certain antibiotics, antifungals, HIV medications, some antihypertensives, and grapefruit juice. If symptoms such as muscle pain, weakness, or fever occur during the course of this medication, immediate medical consultation is necessary, and muscle enzyme levels should be tested if required. Women of childbearing potential should use appropriate contraceptive methods during the course of this medication, and if pregnancy is confirmed, the medication should be discontinued. This drug is not recommended for breastfeeding women, so breastfeeding should be avoided while taking it. In the case of overdose, there is no specific antidote, so treatment should be symptomatic, monitoring liver function and muscle enzyme levels. Keep out of reach of children, and store in the original container to maintain quality.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe allergic reaction, severe rash with fever, blisters, skin peeling, pain in the mucous membranes of the mouth/eyes, severe skin adverse reactions, shortness of breath or difficulty in breathing, asthma attacks, breathing difficulties accompanied by cough and fever, breathing problems, yellowing of the skin or eyes (jaundice), extreme lethargy, liver abnormalities (jaundice), sudden and

Mild side effects

• Weakness
• lethargy
• chest pain
• peripheral edema
• fatigue
• fever
• rhinitis
• hyperglycemia
• hypoglycemia
• weight gain

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is also advisable to store the medication at room temperature between 1°C and 30°C. Do not place it in extremely cold or hot places.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle