Cremadex 250 mg (Clarithromycin)

Adult dose

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment whose creatinine clearance is 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days in these patients. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, or rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for a further 14 days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children 12 years and older: same as adults. For children under 12 years, use clarithromycin dry syrup.

This medicine should not be used in certain patients. Patients who are allergic to any of the components of this drug or have hypersensitivity to similar classes of antibiotics should not be administered this drug. Additionally, patients with certain heart diseases, significantly impaired liver or kidney function, pregnant or breastfeeding women, and patients with central nervous system infections may be at risk if they take this drug. Patients who are taking other medications that may cause heart rhythm problems should not use this drug. Caution should be exercised in certain cases. Patients with poor liver or kidney function, heart disease, elderly patients, and those taking other antibiotics need to be particularly careful when using this drug. Care should also be taken if there is an allergy to specific dyes contained in this drug. When taking this drug, various side effects may occur. Allergic reactions such as shortness of breath, rash, and itching may occur, and any abnormal symptoms should lead to immediate cessation of the drug. Gastrointestinal issues such as abdominal pain, diarrhea, nausea, and vomiting may occur, and rarely severe gastrointestinal diseases such as colitis may develop. Respiratory problems or pneumonia symptoms may also arise, so caution is required. There may be changes in blood counts with reductions in white blood cells or platelets, necessitating regular blood tests. Central nervous system symptoms such as dizziness, anxiety, hallucinations, and seizures may occur, so careful monitoring is needed. Severe rashes or allergic purpura may develop on the skin, and if any abnormal signs appear, immediate consultation with healthcare professionals is required. Liver dysfunction may occur, with symptoms including jaundice, loss of appetite, and abdominal pain, so careful observation is necessary. Kidney function may worsen, requiring kidney function tests as well. This drug has many interactions with other medications, so if you are taking other drugs, you must inform healthcare professionals. Particular caution is warranted when taken with heart-related medications, drugs affecting the liver or kidneys, anticoagulants, or diabetes medications. It is safest not to take this drug during pregnancy or while breastfeeding, and if unavoidable, breastfeeding should be discontinued. Children and elderly patients require special attention and may need dosage adjustments. Regular checks on liver and kidney function, blood tests, and cardiac status are important while taking this drug. In case of overdose, gastrointestinal disturbances or severe neurological symptoms may arise, necessitating immediate medical attention. This drug’s absorption may decrease when taken with other medications, so adherence to proper dosing methods and timing is crucial.

Shock, anaphylactic symptoms, shortness of breath, convulsions, flushing, rash, itching, urticaria, skin rash, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, indigestion, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal erosion, epigastric pain, thirst, tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, stool discoloration, membranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, convulsions, tremors, numbness, behavior changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, increased ALP, increased total bilirubin, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, oliguria, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, hearing impairment, hypoglycemia, purpuric rash, acute generalized exanthematous pustulosis, muscle cramping, musculoskeletal stiffness, myopathy, elevated serum creatinine, increased serum urea, renal failure, nephritis, injection site thrombophlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine discoloration

This medication is sensitive to light and should be stored in a light-protective, sealed container. It is important to maintain a storage temperature between 15 and 30 degrees Celsius at room temperature. Proper storage helps to maintain the drug's efficacy and safety.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle