Famivir Tablet (Famciclovir)

Adult dose

1. Treatment of herpes zoster infection Adults: Administer 750 mg of famciclovir orally once daily for 7 days. Take it at the same time each day. It is preferable to start treatment as soon as symptoms appear after infection. 2. Patients with renal impairment: Since the creatinine clearance of this drug is reduced in patients with renal impairment, adjust the dose with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster infection Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose, twice daily 10～29: 250 mg per dose, once daily 2) If only serum creatinine is known, creatinine clearance can be calculated using the following formulas. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 3) Patients with renal impairment receiving hemodialysis: For patients on hemodialysis, administration every 48 hours is preferable, taking the dialysis interval into account. Since 4 hours of hemodialysis reduces the plasma concentration of this drug by approximately 75%, administer the full dose immediately after dialysis. 3. Patients with hepatic impairment: No dose adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This medicine should not be used by patients who have had an allergic reaction to this drug or its components. Patients with impaired kidney function should use this medicine with caution and may require dosage adjustment. In clinical trials, symptoms such as headache or nausea were reported, but most were mild, and rarely thrombocytopenia or leukopenia may occur. Symptoms like dizziness, drowsiness, and confusion may appear, so it is advisable to avoid driving or operating machinery when experiencing these symptoms. Gastrointestinal symptoms such as nausea, vomiting, abdominal pain, and diarrhea may occur frequently. It is important to periodically check liver function, as abnormalities or rare cases of jaundice may occur. Skin rashes or itching, and rarely severe skin reactions may occur, so vigilance regarding skin changes is necessary. In patients with impaired kidney function, acute kidney failure has rarely been reported, so dosage should be adjusted considering kidney status. This drug cannot cure genital herpes, so even during treatment, sexual contact should be avoided if symptoms persist, and safe sexual practices should be maintained. Safety for pregnant or breastfeeding women has not been fully established; it should be used cautiously only when necessary. Children under 18 years should not use this medicine as its safety and efficacy have not been established. Generally, elderly patients do not require dosage adjustments, but dosage adjustments may be needed in cases of reduced kidney function. In case of overdose of this medicine, appropriate treatment should be sought, and blood dialysis can be used to reduce the drug concentration.

• Headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medicine is sensitive to air and moisture, so it should be stored in a tightly sealed container. The appropriate storage temperature is room temperature between 1 and 30 degrees Celsius, preferably in a dry place with low humidity.

Appearance

White oval film-coated tablet

Package unit

7 tablets (7 tablets/PTPX1)