Proivan Tablet 150 mg (Ibandronic Acid Monohydrate)

Adult dose

Take 1 tablet regularly once a month on the same day in the morning before consuming food, beverages (excluding water), or other oral medications or dietary supplements (including calcium) with a sufficient quantity of water at least 1 hour prior. - This medication should be swallowed with a sufficient amount (180-240 mL) of water while standing or sitting upright, and lying down for 60 minutes after taking it is prohibited. - Mineral water may decrease the absorption of this medication.

Child dose

Efficacy and safety in children under 18 years have not been studied.

This medication should not be used by certain patients. For example, individuals allergic to this medication or its components, patients with untreated hypocalcemia, those unable to sit or stand upright for at least 60 minutes, individuals with esophageal function problems that impede swallowing, and those with lactose intolerance or certain genetic metabolic disorders should not take this medication. In cases of severe renal impairment, the administration of this medication should be done with caution, following a doctor's instructions. Adverse effects such as gastrointestinal discomfort, nausea, abdominal pain, diarrhea, headache, muscle pain, joint pain, and rash may occur upon taking this medication. Particularly during initial administration, flu-like symptoms may temporarily appear, so caution is advised. Severe esophageal issues such as esophagitis, esophageal ulcers, and esophageal erosion may arise, necessitating that patients remain upright or standing for at least 60 minutes after taking this medication. If difficulty swallowing or chest pain occurs, take this medication immediately and consult a doctor. Bisphosphonate medications may cause serious side effects such as osteonecrosis of the jaw, so consult your doctor before any dental treatments, and avoid excessive dental treatment while taking this medication. Additionally, this medication may have impaired absorption when taken with food, calcium, aluminum, magnesium, iron, or other components, so other medications or foods should not be consumed for at least 1 hour after taking this medication. It is safest for pregnant or nursing women to avoid this medication, and safety and efficacy have not been established for children under 18 years of age. In case of overdose, gastrointestinal disturbances or hypocalcemia may occur, so strict adherence to the prescribed dosage is essential, and medical attention should be sought immediately if symptoms arise. Lastly, keep this medication out of the reach of children and dispose of expired medications properly to avoid environmental harm.

Serious side effects

• Urticaria, angioedema, facial edema → severe allergic reaction
• Uveitis, scleritis, and other eye inflammations
• Stevens-Johnson syndrome, erythema multiforme, bullous dermatitis → severe skin reactions
• Osteonecrosis of the jaw, osteonecrosis of the external auditory canal → severe swelling or abnormal urination
• Anaphylactic reactions/shock → severe allergic reaction
• Asthma exacerbation → respiratory issues
• Severe esophagitis, esophageal ulcers, esophageal erosions, bleeding, esophageal strictures, perforation
• Atypical fractures

Mild side effects

• Dyspepsia
• nausea
• abdominal pain
• diarrhea
• flatulence
• gastroesophageal reflux disease
• headache
• flu-like illness
• fatigue
• muscle pain

This medication should be stored in a tightly closed container to protect it from air and moisture. It is essential to maintain a storage temperature between 1 to 30 degrees Celsius to preserve the medication's effectiveness for a long period.

Appearance

White to almost white rectangular film-coated tablet

Package unit

1 tablet/PTP