Oliet Capsule 60 mg (Orlistat)

Adult dose

○ Adults The recommended dose is 120 mg of orlistat per dose, orally 3 times daily, with a fat-containing meal or within 1 hour after a meal. Patients should continue a nutritionally balanced, mildly low-calorie diet in which approximately 30 % of calories are derived from fat. Daily intake of fat, carbohydrate, and protein should be distributed evenly among three meals. This product may be omitted if a meal is missed or contains no fat. Because this product may reduce the absorption of some fat-soluble vitamins and beta-carotene, patients are advised to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition. The vitamin supplement should be taken at least 2 hours before this product or at least 2 hours after it, such as at bedtime. Taking more than 120 mg per dose 3 times daily does not increase the effectiveness of this product. Based on fecal fat measurements, the effect of this product is apparent approximately 24 ∼ 48 hours after administration. After discontinuation, fecal fat content generally returns to pretreatment levels within 48 ∼ 72 hours. The efficacy and safety of this product have not been evaluated for use beyond 4 years. ○ Studies have not been conducted in patients with hepatic and/or renal impairment or in elderly patients.

Child dose

Studies have not been conducted in children under 12 years of age.

This drug should not be used in patients with chronic malabsorption syndrome or cholestasis, patients who are allergic to this drug or any of its components, pregnant women, women who may become pregnant, and nursing mothers. Liver damage has been reported infrequently; therefore, if symptoms of liver dysfunction occur, notify a doctor immediately and discontinue use of this drug. Patients with history of hyperoxaluria or calcium oxalate kidney stones should use this drug with caution, as urinary oxalate excretion may increase. Gastrointestinal adverse effects are commonly observed when taking this drug, mainly worsening with meals high in fat. Adverse effects are mostly mild and transient, occurring primarily within 3 months of starting treatment and tend to decrease over time. Gastrointestinal symptoms may include fatty stools, abdominal distension, flatulence, constipation, and in some patients, fecal incontinence may occur. During the use of this drug, absorption of fat-soluble vitamins and beta-carotene may be reduced, thus taking vitamin supplements is recommended. Vitamin supplements should be taken at least 2 hours after taking this drug or at least 2 hours before taking this drug for optimal effectiveness. This medication may increase gastrointestinal side effects when taken with high-fat meals; hence, fat intake should be distributed evenly over three meals per day. It is advisable for pregnant or nursing women not to take this drug, as weight loss during pregnancy may be harmful to the fetus. This drug should not be used in children under 12 years old as its safety and efficacy have not been established. If symptoms of liver dysfunction occur during the use of this drug, immediate medical attention should be sought, as this may lead to liver damage. This drug has a weight loss effect, which can affect blood glucose control in diabetic patients, requiring potential dosage adjustment of blood glucose control medications. Excessive weight loss may increase the risk of gallstones, so caution is advised. As it may affect blood coagulation, patients taking oral anticoagulants should undergo regular blood coagulation tests. This drug may interact with various medications; therefore, if other medications are being taken, consultation with a physician or pharmacist is necessary. In case of overdose, patients should be monitored for 24 hours and necessary measures should be taken. This drug should be kept out of reach of children and stored protected from light and moisture.

• Fatty stools
• abdominal bloating and flatulence
• increased frequency of stools
• fatty stools
• oily stools
• increased bowel movements
• fecal incontinence
• abdominal pain/discomfort
• nausea
• infectious diarrhea

This drug may be sensitive to air, light, and moisture, so it should always be stored in a tightly sealed container. Additionally, it should be kept in a cool place at a temperature below 25 degrees Celsius to maintain its effectiveness.

Appearance

White or off-white powder or granules inside yellow hard capsules

Package unit

90 capsules (10 capsules/PTPX9), 300 capsules/bottle