Clarithromycin 250 mg Tablets

Adult dose

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, or rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily for 14 days together with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years and older: Same as adults. For children under 12 years, use clarithromycin dry syrup.

This medication should not be used by patients who are allergic to certain components. Those with a history of allergic reactions to clarithromycin or similar antibiotics should also avoid administration. Patients with a history of arrhythmias or prolonged QT interval should be cautious as it may pose risks. It is also unsafe for patients with very poor liver function or severely impaired kidney function to use this medication. Women who are pregnant or breastfeeding should not take this medication. This medication can interact with several other drugs; please inform your healthcare provider of any medications you are currently taking. Caution is particularly needed when used in conjunction with medications that can affect the heart, certain antibiotics, antidiabetics, and immunosuppressants. If any abnormal symptoms such as allergic reactions, gastrointestinal disturbances, breathing difficulties, skin rash, or hearing abnormalities occur during treatment, consult your healthcare provider immediately. Long-term or high-dose use may lead to hearing damage or tinnitus; if symptoms arise, treatment should be stopped. Elderly patients or those with impaired liver or kidney function may require dosage adjustments, so they should follow their healthcare provider's instructions. This medication may require caution during driving or operating machinery, so effects should be monitored while taking it. Overdose may cause gastrointestinal disturbances or psychiatric symptoms, so it is essential to adhere to the prescribed dosage and administration. During treatment with this medication, it is crucial to take it consistently for the prescribed duration to prevent antibiotic resistance.

shock, anaphylactic symptoms, respiratory distress, convulsions, flushing, rash, itching, hives, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, bloating, diarrhea, oral erosion, upper abdominal pain, thirst, tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, discoloration of stool, membrane colitis, hemorrhagic colitis, fever, cough, respiratory distress, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, taste loss, smell loss, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, derealization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste disturbance, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, hearing impairment, hypoglycemia, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, acute generalized exanthematous pustulosis, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, angioedema, decreased appetite, insomnia, nervousness, auditory sensitivity, confusion, abnormal dreams, muscle cramps, musculoskeletal rigidity, myopathy, vasodilation, angioedema, elevated serum creatinine, elevated serum urea, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine color abnormalities, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, tongue discoloration, hyperhidrosis, acne, Henoch-Schonlein purpura

If for domestic use, this medication should be stored in an airtight container that does not allow air in, at room temperature between 1°C and 30°C. For export products, store in a sealed container in a dry place away from moisture, shielding it from light to preserve its efficacy and prevent deterioration.

Appearance

[Domestically Available] Yellow oval film-coated tablet with vanilla flavor [For Export] Yellow rectangular film-coated tablet

Package unit

Domestic Use - 30 tablets/bottle, Domestic Use - 100 tablets/bottle, For Export - 20 tablets/box [(10 tablets/PTPX2)], For Export - 100 tablets/box [(10 tablets/PTPX10)]