Diagryl-MEX Controlled Release Tablet 2/500 Milligrams

Adult dose

The initial dose of this medication is Glimepiride/Metformin Hydrochloride 2/500mg once daily, adjusted according to the patient's condition. When substituted in combination therapy, administer the same daily dose as previously given, with a maximum recommended dosage of Glimepiride 8mg and Metformin 2000mg. This medication is taken once daily before or during the main meal. If a dose is missed, the next dose should not exceed the recommended single dose.

This medication can cause severe lactic acidosis or hypoglycemia, which requires caution. Particularly, if renal function rapidly declines, the risk of lactic acidosis may increase due to drug accumulation. If dehydration symptoms occur, the medication should be temporarily discontinued, and consultation with a physician is advised. Additionally, the risk of cardiovascular disease may increase, so careful observation is necessary before and after treatment. It should not be administered to patients with type 1 diabetes, acute metabolic acidosis, or severe liver or kidney dysfunction. Patients undergoing surgery or those with severe infections or serious trauma may also need to temporarily discontinue use. Elderly patients or those with poor nutritional status and irregular eating habits should also exercise caution due to the risk of hypoglycemia. Gastrointestinal disturbances (such as diarrhea and vomiting) may occur during the initial use of this medication, but these typically improve over time. If allergic reactions, severe skin rashes, or blood abnormalities occur, notify a physician immediately. Do not crush or chew this medication; swallow it whole, and regular monitoring of blood sugar and kidney function is required during treatment. Alcohol consumption may affect the drug's efficacy, so it is better to avoid it. It is safest not to use this medication during pregnancy or breastfeeding. When used in combination with other drugs, the possibility of interactions exists, so always consult healthcare professionals. In cases of overdose, serious side effects such as hypoglycemia or lactic acidosis can occur, necessitating immediate emergency treatment. Especially in the elderly, where renal function decline is common, dose adjustment and regular monitoring are important. This medication should be stored out of the reach of children for safety.

Serious side effects

Rash, severe swelling (edema), difficulty breathing, chest tightness, severe allergic reactions, liver function damage, hepatic failure, yellowing of the skin (jaundice), severe lactic acidosis, hypoglycemia, severe hypoglycemic symptoms (headaches, loss of consciousness, coma, vision changes, numbness), thrombocytopenia, hemolytic anemia, leukopenia, severe allergic reactions, hypotension, thrombocytopenic purpura, severe edema, urination abnormalities.

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal swelling
• bloating
• loss of appetite
• thrombocytopenia
• taste disturbance
• metallic taste
• itching

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. The recommended storage temperature is between 1 to 30 degrees Celsius at room temperature. Proper storage will help maintain the drug's efficacy.

Appearance

White, rectangular, film-coated, triple-layered tablet

Package unit

30 tablets/bottle