TenPramin Injection

Adult dosage

Adults should receive a maximum intravenous drip infusion of 1 to 1.5 g per day per kg body weight of total amino acids. The infusion rate should ideally involve a total amino acid concentration of about 10 g over 60 minutes, following the principle of administering 30 to 40 drops over 1 minute.

Children's dosage

In children, the dosage and infusion rate should be adjusted appropriately.

This drug must be used strictly according to the physician's directions. It should not be administered to patients who have hepatic coma or are at risk of hepatic coma, severe renal dysfunction, or problems with nitrogen metabolism. Patients with severe heart failure, pulmonary edema, minimal or no urine output, acidosis, fluid overload, hypokalemia, shock, or a history of myocardial infarction should also avoid this medication. Care should be taken when administering to patients with congestive heart failure, hepatic impairment, or renal impairment, and it is essential to consult a physician before administration. Rarely, hypersensitivity reactions such as skin rashes may occur; if such symptoms arise, use should be stopped immediately. Gastrointestinal symptoms such as nausea or vomiting, discomfort in the chest, rapid heartbeat, or hypertension may develop, so caution is advised. Administering the drug too quickly can lead to acidosis, so attention should be paid to the rate of administration. Symptoms such as chills, fever, headache, difficulty breathing, shock, bronchospasm, or urinary spasm may also occasionally occur. Metabolic issues can result in acidosis, hypophosphatemia, alkalosis, elevated blood sugar, diabetes, dehydration, hypoglycemia, elevated liver enzymes, vitamin imbalance, electrolyte disturbances, and hyperammonemia in children. Patients with impaired liver or kidney function may experience elevated blood urea nitrogen levels, thus caution is required. Patients with severely decreased liver function may present with serious symptoms such as amino acid imbalance in the blood, metabolic alkalosis, or coma. Careful monitoring of electrolyte balance is crucial when using large doses or with electrolyte-containing solutions. Excess doses may lead to metabolic alkalosis; hence solutions containing acetate ions should be used with caution. Patients with a history of kidney, lung, or heart disease should be cautious to avoid fluid overload. Diabetic patients should frequently monitor and manage their blood sugar levels while using this drug. When used with tetracycline antibiotics, the protein-saving effects of amino acids may be reduced. The safety of this drug has not been established for pregnant women; it should only be used when the benefits outweigh the risks. In children, as liver function may be immature, it is necessary to maintain lower concentrations and frequently check blood ammonia levels. Elderly individuals may have decreased body function, so care is needed to slow the rate of administration and reduce the dosage. The drug should be administered slowly through intravenous infusion, as rapid administration may cause chills or vomiting. The solution should be warmed to approximately body temperature for use, and thorough aseptic techniques should be maintained during preparation and handling. Any residual liquid or non-transparent solution should not be used, and it should be used quickly after mixing, stored in the refrigerator, and used within 24 hours. If crystals form, they should be dissolved by warming and cooled to body temperature before use. When storing, do not open the packaging, and do not use if the solution is discolored, leaked, or if the protective film on the rubber stopper is peeling off. It must be used precisely according to the graduated markings on the container.

Serious side effects

Severe allergic reactions due to hypersensitivity (symptoms such as rash may appear rarely), dyspnea, respiratory arrest, shock, bronchospasm, hepatic failure, renal failure, loss of perception, coma.

Mild side effects

• Rash
• nausea
• vomiting
• chest discomfort
• palpitations
• tachycardia
• hypertension
• metabolic acidosis
• hypophosphatemia
• alkalosis

This drug should be stored in a sealed container to prevent air or moisture exposure, ideally at room temperature between 1 to 30 degrees Celsius. Storing it this way will help maintain its efficacy for a longer period.

Appearance

A clear solution that is colorless or pale yellow, contained in a transparent polypropylene container for injection.

Package unit

250 milliliters