N.A.K Injection 200

Adult administration

This medication should be diluted in Ringer's solution, dextrose injection, or normal saline to a concentration of 0.3% (40 mEq/L as potassium) and administered by slow intravenous infusion. The infusion rate should not exceed 20 mEq per hour. The daily dosage should not exceed 7.5g (100 mEq as potassium) of this medication. Dosage and infusion rate should be appropriately adjusted according to age, body weight, and symptoms.

This medication can cause severe allergic reactions, so if any hypersensitivity symptoms occur, administration should be stopped immediately and appropriate treatment should be sought. Due to the presence of potassium, there is a risk of elevated serum potassium levels, especially for patients with poor kidney function, heart disease, or those taking medications that increase potassium levels, so caution is advised. This medication can also increase sodium and chloride levels, potentially causing electrolyte imbalances; thus, it should be used cautiously in patients with risks for fluid overload such as hypertension, liver disease, or heart failure. It may cause symptoms of hyponatremia (low sodium levels in the blood) such as headaches, nausea, and seizures, so high-risk patients should have regular blood tests. During administration, the dosage and rate should be adjusted to prevent fluid overload and electrolyte imbalance, and serum electrolyte levels, kidney function, and acid-base balance should be carefully monitored as needed. Patients with specific diseases or hypersensitivity to this medication should not receive it, and those with impaired kidney function or heart disease should use it with even more caution. Side effects of this medication may include muscle weakness, cardiac irregularities, and gastrointestinal discomfort caused by excess potassium; therefore, it is important to inform medical personnel immediately if any abnormal symptoms occur. For long-term use, serum potassium levels, kidney function, and ECG changes should be regularly monitored, and administration should be discontinued if abnormalities are found. This medication can interact with other drugs, so particularly when taking medications that increase potassium levels or affect kidney function, consult healthcare personnel and frequently check serum potassium levels. Pregnant or nursing women should use this medication cautiously as its safety has not been sufficiently established. Pediatric and elderly patients may have decreased ability to regulate fluids and electrolytes, necessitating closer monitoring and adjustment during administration. In case of overdose, severe hyperkalemia can occur, so if symptoms appear, administration should be stopped immediately, and appropriate emergency measures should be taken. Prior to administration, the injection site should be cleaned and disinfected to prevent infection, and once opened, it should be used immediately with any remaining drug not being reused. This medication must be diluted before use, and caution should be taken as administering it undiluted may lead to cardiac side effects. During storage, the container should not be damaged, and it should only be used while the contents are clear; if any abnormalities are present, it should not be used.

Serious side effects

Hypersensitivity reactions including anaphylaxis, ECG abnormalities, cardiac arrest, signs of hyperkalemia (limb paralysis, arrhythmias, heart block, etc.), hyponatremic encephalopathy, headaches, nausea, seizures, drowsiness, vomiting, acute hyponatremic encephalopathy, potentially fatal brain damage, hypernatremia, hyperchloremia, pulmonary edema from fluid overload, acute renal injury, severe rash with fever, blisters, skin peeling, oral/ocular lesions.

Mild side effects

• Nausea
• vomiting
• abdominal discomfort
• diarrhea
• generalized rash and erythema
• rash
• vomiting
• hypertension
• tachycardia
• chills

This medication should be stored in a sealed container to prevent air or moisture from entering, and it is safest to keep it at room temperature between 1 to 30 degrees Celsius. Storing it this way will help maintain the medication's effectiveness for a longer period.

Appearance

An injection containing a colorless and transparent liquid in a polypropylene container

Package unit

100 milliliters/bottle