Neo Maril M Tablet 1/500 mg

Adult dose

This medication is administered 1 to 2 times daily before or with meals. The dosage can be adjusted based on the patient's current treatment regimen, effectiveness, and tolerance, and appropriate blood sugar monitoring should be performed for this. Generally, treatment is initiated at a low dose, and dosage may be adjusted based on the medication currently taken by the patient and their blood sugar levels. In clinical trials, the initial daily dose was Glimepiride/Metformin Hydrochloride 2mg/500mg, with gradual increases according to blood sugar monitoring results up to Glimepiride/Metformin Hydrochloride 8mg/2000mg. There is minimal additional effect once daily doses of single-agent Glimepiride exceed 4mg, although some patients have exhibited better metabolic control when doses are increased to 6mg (or 8mg). For alternative therapy using combination therapy, dosing should be based on the current dosing regimen of Glimepiride and Metformin Hydrochloride. Even if a dose is missed, one should not exceed the prescribed dose at the next administration.

This medication can accumulate in the body and potentially cause severe lactic acidosis or hypoglycemia if kidney function decreases severely, so renal function must be checked before treatment and monitored regularly. If there are symptoms of dehydration or if medications that may affect kidney function are being taken, administration of this medication should be temporarily halted and consulting a doctor is necessary. In patients with cardiovascular diseases, there is an increased risk of cardiovascular death, so caution is needed when using this medication. Insulin-dependent diabetes patients, those with acute metabolic acidosis, severe liver or kidney function impairment, pregnant women, and nursing mothers should not take this medication. Patients at high risk of hypoglycemia, especially the elderly, malnourished individuals, those with irregular meal intakes, or those engaging in vigorous exercise should closely monitor blood sugar levels during the initial period of taking this medication. Gastrointestinal symptoms (diarrhea, nausea, vomiting, etc.) may occur during treatment, but they are mostly temporary and can be reduced by taking the medication with meals. If allergic reactions or severe skin rashes occur, it is essential to inform a doctor immediately, and hematological abnormalities must also be regularly checked. This medication can reduce vitamin B12 levels, so regular monitoring of vitamin B12 levels is necessary during long-term use, and supplementation should be provided if needed. During the course of this medication, excessive alcohol consumption should be avoided, as both acute and chronic alcohol intake may increase the risk of lactic acidosis. Due to the many interactions with other medications, it is vital to consult a doctor or pharmacist when starting or stopping new medications and to closely monitor blood sugar control. If pregnant or planning to become pregnant, it is recommended to switch to insulin therapy instead of using this medication. Special attention is required for children and the elderly, as elderly patients especially need dosage adjustments and regular kidney function tests due to decreased renal function. Caution should be taken while driving or operating machinery as hypoglycemia may impair agility. In case of overdose, severe hypoglycemia or lactic acidosis may occur, so if symptoms appear, a medical institution should be visited immediately, and appropriate treatment should be received in emergencies.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, hypotension, shock, severe allergic reactions, kidney function abnormalities, liver abnormalities (liver dysfunction, jaundice), severe skin adverse reactions (severe rash, blisters, skin peeling, mucosal pain), severe hypoglycemia (loss of consciousness, coma, cerebral seizures), lactic acidosis, severe neurological symptoms (seizures, altered consciousness, vision changes, paralysis), thrombocytopenic purpura, severe edema, cardiac arrest

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distention, loss of appetite, indigestion, constipation, abdominal pain), taste disorders, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia, decreased and deficient vitamin B12, increased liver enzymes, hepatitis, allergic vasculitis, photosensitivity skin reactions, decreased serum sodium concentration, hypothyroidism, magnesium deficiency during diarrhea, brain

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is also safe to store at room temperature that is neither too hot nor too cold, specifically between 1 and 30 degrees Celsius.

Appearance

Light pink oblong film-coated tablet

Package unit

30 tablets (10 tablets/PTP x 3)