Renvela 0.8 grams (Sevelamer Carbonate)

Adult dose

This medicine should be taken 3 times daily with meals. When taking the powder, completely mix 1 sachet of this medicine with at least 30mL of water and take within 30 minutes; resuspend before taking. 1) Administration to patients not taking phosphate binders The recommended initial dose of this medicine is 0.8g to 1.6g. Take 1~2 sachets of this medicine with each meal according to the serum phosphorus level as follows. 5.5 - 7.5 ㎎/dL: 1 sachet per dose, 3 times daily with meals 7.5 ㎎/dL or higher: 2 sachets per dose, 3 times daily with meals 2) Substitution of this medicine in patients taking sevelamer hydrochloride tablets When substituting this medicine for sevelamer hydrochloride tablets, administer the same dose. Appropriate dose adjustment may be necessary to achieve the target serum phosphorus level. The maximum daily dose of sevelamer carbonate studied in patients with chronic kidney disease receiving dialysis was 14g. 3) Substitution between sevelamer carbonate tablets and powder When substituting between sevelamer carbonate tablets and powder, administer the same dose. Appropriate dose adjustment may be necessary to achieve the target serum phosphorus level. 4) Substitution of this medicine in patients taking calcium acetate preparations 1 tablet per dose, 3 times daily: 1 sachet per dose, 3 times daily 2 tablets per dose, 3 times daily: 2 sachets per dose, 3 times daily 3 tablets per dose, 3 times daily: 3 sachets per dose, 3 times daily 5) Dose adjustment in all patients taking this medicine If necessary, increase or decrease the dose of this medicine by 0.8g, 3 times daily with meals, at 2-week intervals until the target serum phosphorus level is achieved.

This medication should not be used by patients who are allergic to the main ingredient or excipients. Patients with hypophosphatemia should not take this medication. Patients with bowel obstruction or blockage should avoid this medication as it may expand in the intestines and pose a risk of intestinal perforation. Patients with bowel strictures or constipation should use this medication cautiously, as there is a risk of bowel obstruction or perforation occurring during treatment. This medication primarily has gastrointestinal side effects, including vomiting, nausea, diarrhea, dyspepsia, abdominal pain, bloating, and constipation, which have been commonly reported. Particularly in peritoneal dialysis patients, peritonitis may occur, so any symptoms should be immediately reported to healthcare professionals. If constipation worsens or new constipation develops, appropriate treatment is needed to prevent serious bowel complications. This medication does not contain calcium or alkaline components, therefore calcium levels in the blood should be monitored regularly, and calcium supplements should be taken if necessary. With prolonged use, levels of fat-soluble vitamins A, D, E, K, and folic acid may decrease, so regular vitamin status checks and supplementation are recommended. Patients with dysphagia or esophageal issues should use the powder form instead of tablets. If symptoms such as severe constipation, persistent abdominal pain, or vomiting occur, the medication should be stopped immediately and consult a healthcare professional. This medication may interfere with the absorption of other oral medications; therefore, it is recommended to take it at least 1 hour before or 3 hours after other medications. Especially, it should not be taken simultaneously with ciprofloxacin, and blood concentration levels should be monitored in patients taking other medications. The safety of this medication in pregnancy has not been established, so women who are pregnant or may become pregnant should consult their physician before taking it. Nursing mothers should also consider the benefits and risks of breastfeeding and medication as it is not clear whether this medication is excreted in breast milk. The use of this medication is not recommended for children under 18 years as its safety and efficacy have not been established. Elderly patients should generally start with a lower dose and be closely monitored. There are no specific reports of overdose for this medication, but care should be taken not to exceed the recommended dosage. This medication must be mixed well with water and taken within 30 minutes with food, and moisture should be avoided during storage. If severe gastrointestinal symptoms or inflammatory bowel conditions occur while taking this medication, treatment should be stopped immediately and healthcare professionals should be consulted.

• vomiting
• nausea
• diarrhea
• indigestion
• abdominal pain
• bloating
• constipation
• itching
• rash
• fecal impaction

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, it is advisable to store the medication at room temperature, neither too hot nor too cold.

Appearance

Pale yellow powder with a citrus scent

Package unit

90 packets