Cenex Capsule (Celecoxib)

Adult dose

The minimum recommended dose of this drug should be adjusted for each patient, and it may be administered regardless of meals. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or 100 mg twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks of treatment with 400 mg daily, another treatment option should be considered. 4. Acute pain and primary dysmenorrhea: The recommended initial dose is 400 mg of celecoxib, with an additional 200 mg on the first day of administration if needed. From the second day of administration, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment: In patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication can pose a risk of gastrointestinal bleeding if taken by individuals who consume large amounts of alcohol daily, so it is essential to consult a doctor or pharmacist. This medication may increase the risk of cardiovascular problems such as myocardial infarction or stroke; therefore, it should only be used at the lowest effective dose for the shortest possible duration, and any cardiovascular symptoms should be reported to healthcare professionals immediately. Serious adverse reactions, such as gastrointestinal perforation, ulcers, and bleeding, can occur, particularly in older adults or those with a history of gastrointestinal disorders, and medical attention should be sought immediately if gastrointestinal symptoms appear. This medication should not be administered to patients with certain allergic histories or serious conditions such as severe liver or kidney diseases, active peptic ulcers, or congestive heart failure. Patients with impaired liver or kidney function or a history of cardiovascular diseases, hypertension, asthma, or diabetes should use this medication with caution, and regular monitoring may be necessary. It is advisable to avoid driving or operating machinery while taking this medication due to the risk of dizziness or drowsiness. This medication may interact with various other drugs, so it is crucial to inform healthcare professionals about any other medications being taken. Pregnant or potentially pregnant women, as well as nursing mothers, should not take this medication, and it should be discontinued immediately if pregnancy occurs while on this medication. Elderly patients may have decreased kidney and liver function, so special monitoring is necessary when taking this medication. Regular blood tests and liver/kidney function assessments are required for those on long-term use of this medication, and any adverse symptoms should prompt immediate consultation with healthcare professionals. In case of overdose, symptoms such as lethargy, drowsiness, nausea, vomiting, and gastrointestinal bleeding may occur, and immediate medical attention is needed. This medication should be kept out of reach of children, and transferring it to other containers should be avoided.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcer, bleeding, bronchitis, sinusitis, upper respiratory infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental diseases, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, blistering dermatitis, peripheral edema, facial edema, influenza-like illness, injury, taste disturbance, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, urinary incontinence, urinary tract infection, visual disturbances, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, headache, migraine, neuralgia, neuropathy, sensory disturbances, cerebral infarction, aseptic meningitis, ataxia, suicide, hyposmia, ageusia, allergic reaction, weakness, chest pain, fluid retention, systemic edema, facial swelling, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reaction, vasculitis, angioedema, upper respiratory infection, shingles, wound infection, gingivitis, herpes simplex, herpes zoster, bacterial infection, fungal infection, soft tissue infection, viral infection, moniliasis, genital moniliasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast changes, thoracic neoplasm, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, hepatic necrosis, increased serum sodium, increased serum potassium, increased BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, synovial cyst, arthralgia, arthropathy, skeletal anomalies, myalgia, cervical dystonia, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in various parts of the body, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, epistaxis, thrombocytopenic purpura, anemia, thrombocytopenia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, eosinophilic inflammation, contact dermatitis, injection site reaction, skin nodules, visual disturbances, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorders, chest pain, anaphylactic reaction, hallucinations, cerebral hemorrhage, aseptic meningitis, ageusia, hyposmia, conjunctivitis, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, liver failure, fulminant hepatitis, hepatic necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, minimal change disease in glomerulonephritis, female infertility

This medication should be stored in an airtight container and kept at room temperature between 15 degrees and 30 degrees Celsius. This storage helps maintain its effectiveness and prevents degradation.

Appearance

A white capsule filled with white to light yellow powder with a yellow band on both ends.

Package unit

For domestic use - 30 capsules/bottle, For domestic use - 100 capsules/bottle, For export - 100 capsules/PTP [(10 capsules/PTP) x 10]