Lefren Capsule 75 mg (Pregabalin)

Adult dose

This medication is administered orally in divided doses of the total daily dose twice a day, regardless of food. 1. Neuropathic Pain - Peripheral neuropathic pain: Starting dose of 150 mg per day, which may be increased to 300 mg per day within 3 to 7 days, and may be increased to a maximum of 600 mg if necessary every 7 days. - Central neuropathic pain: Starting dose of 150 mg per day, which may be increased to 300 mg per day after one week.

Child dose

There is insufficient safety and efficacy data to recommend use in children under 12 years and adolescents aged 12 to 17.

This medication may increase the risk of suicidal thoughts and behaviors; therefore, it is important to closely monitor for symptoms of depression, mood changes, or abnormal behavioral changes during treatment. Patients who are allergic to pregabalin or any ingredient in this medication, or those with genetic lactose intolerance, should not take this medication. Diabetes patients should be cautious, as weight gain may necessitate dose adjustments of blood sugar control medications. If serious allergic reactions such as angioedema occur, discontinue the medication immediately and consult a healthcare provider. Elderly patients may experience increased dizziness or drowsiness; caution should be exercised when starting the medication. This medication may temporarily cause visual disturbances such as blurred vision, so patients should inform healthcare providers of any changes in vision. Stopping the medication suddenly may result in withdrawal symptoms such as insomnia, headache, and anxiety, so it should be discontinued gradually according to a doctor's instructions. Due to the risk of drug abuse, patients with a history of substance misuse should be particularly cautious, and watch for signs of misuse or dependency. Patients with impaired renal function should have their dosages adjusted, and those with severe heart disease should take this medication cautiously. Caution is advised when combining with other medications that have a central nervous system depressant effect or opioids, as there is a risk of respiratory depression. Pregnant women should avoid this medication during early pregnancy due to potential risks of fetal malformations, and women of childbearing potential should use effective contraception while on this medication. Breastfeeding women should discuss with their doctors, as this medication may be passed into breast milk and affect the infant, possibly necessitating discontinuation of breastfeeding or the medication. There is a risk of accidents due to dizziness or drowsiness when driving or operating machinery, so caution must be taken if these symptoms occur during initial treatment. This medication can cause serious skin reactions, so if symptoms such as a rash, swelling, or fever occur, discontinue use immediately and inform a healthcare provider. In the event of overdose, symptoms such as confusion, drowsiness, and seizures may occur; strict adherence to the prescribed dosage is important, and in case of overdose, seek emergency medical assistance immediately. Store this medication out of reach of children and do not transfer it to another container to maintain its quality.

Serious side effects

Urticaria, angioedema, facial swelling, swelling of the face, lips, and upper airways, Stevens-Johnson syndrome, toxic epidermal necrolysis, cold sweats, severe allergic reactions, severe rash accompanied by high fever, blisters, skin peeling, pain in oral/ocular mucosa, severe skin reactions, respiratory difficulties, difficulty breathing, pulmonary edema, respiratory depression, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever,

Mild side effects

• Confusion
• disorientation
• hypersensitivity
• depression
• euphoria
• decreased libido
• insomnia
• depersonalization
• sexual dysfunction
• restlessness

This medication should be kept in a tightly sealed container to protect it from air and moisture, and it is best stored in a cool place between 15 and 30 degrees Celsius. Storing it this way helps maintain its effectiveness over time.

Appearance

Hard capsule with upper part reddish-brown and lower part white

Package unit

30 capsules/bottle, 60 capsules/bottle