Miaril M Tablet 1/250mg

Adult dose

This medicine is administered 1 to 2 times a day before meals or with meals. The dosage can be adjusted based on each patient's current therapy, efficacy, and tolerability, and appropriate blood sugar monitoring should be conducted for this purpose. Typically, treatment begins with a low dose, and the dose can be adjusted according to the patient's current medication and blood sugar levels. In clinical trials, the initial daily dose was glimepiride/metformin hydrochloride.

This medicine can cause severe lactic acidosis or hypoglycemia, so administration should be temporarily suspended if there is a rapid decline in kidney function or signs of dehydration. It should not be used in patients with a kidney function of less than 45 mL/min/1.73 m2, and caution is needed in situations where kidney function may change. Additionally, it should be used carefully in patients at risk of cardiovascular disease, considering the potential for increased cardiovascular mortality. This medicine is not administered to patients with insulin-dependent diabetes, acute metabolic acidosis, severe liver dysfunction, pregnant or breastfeeding women, and severe renal impairment. Caution is also needed in patients with excessive alcohol intake, severe infections, or malnutrition. During the initial stages of treatment, there is a high risk of hypoglycemia, so the patient's condition should be carefully monitored, and immediate action should be taken if hypoglycemic symptoms arise. It is important to regularly check blood sugar levels, kidney function, hematological tests, and vitamin B12 levels while taking this medicine. Moreover, there may be drug interactions, so consultation with a doctor or pharmacist is required if other medications are taken concurrently. In cases of pregnancy or breastfeeding, switching to insulin therapy is recommended instead of this medicine. When administering to children or the elderly, careful monitoring and dose adjustment are necessary. In case of overdose, hypoglycemic symptoms may appear, and immediate medical attention is needed; in severe cases, blood dialysis may be required. This medicine should be stored out of the reach of children, and it is advised not to transfer it to other containers.

Serious side effects

• Urticaria, severe swelling (edema), difficulty breathing, severe allergic reactions.
• Severe skin reactions with high fever, severe rashes, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, etc.
• Jaundice of the skin or eyes, liver abnormalities.
• Sudden and severe headaches, seizures, confusion, visual disturbances, paralysis, and other serious neurological symptoms.
• Rapid decrease in urine output, severe generalized swelling, high blood pressure accompanied by severe edema or urinary abnormalities.
• Hypoglycemia.

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain), discomfort or metallic taste, visual impairment, taste disturbance, rash, itching, thrombocytopenia, leukopenia, hemolytic anemia, anemia, agranulocytosis, pancytopenia, decrease in vitamin B12 and peripheral neuropathy, increased liver enzymes, hepatitis, liver damage, allergic vasculitis, skin photosensitivity.

This medicine should be stored in a tightly closed container to prevent air from entering, and it is better to keep it at room temperature between 1 and 30 degrees Celsius. Proper storage maintains the effectiveness of the medicine and prevents deterioration.

Appearance

White rectangular film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle