Metformin Plus Tablet

Adult dose

This medication is administered 1 to 2 times a day, right before meals or with meals. Treatment may start at a low dose, and the dosage may be gradually increased based on blood sugar monitoring results. In clinical studies, the initial daily dose was 2mg/500mg of Glymeperide/Metformin Hydrochloride, and doses as high as 8mg/2000mg have been administered. When used as an alternative therapy for combination therapy, it should be dosed according to the currently used Glymeperide and Metformin.

This medication can cause severe lactic acidosis or hypoglycemia, especially in cases of rapidly declining renal function. It is advisable to temporarily discontinue this medication and consult a doctor if dehydration occurs. Patients with renal function below 45 mL/min/1.73 m² should not use this medication, and treatment should be temporarily halted in situations where renal function may fluctuate. There may be a risk of cardiovascular diseases; therefore, thorough consultation with a doctor is needed before and after taking this medication. This medication is not to be used in certain patients such as those with insulin-dependent diabetes, acute metabolic acidosis, severe liver dysfunction, and others. Women who are pregnant or breastfeeding should not take this medication. The risk of hypoglycemia is high during the initial dosing of this medication, so seniors, irregular eaters, and patients with high alcohol intake must be closely monitored. Gastrointestinal disturbances (such as diarrhea, nausea, vomiting, etc.) may occur during the course of taking this medication, but most are temporary. If allergic reactions or severe skin rashes occur, it is necessary to inform a doctor immediately. Vitamin B12 deficiency may occur; therefore, regular blood tests are needed for monitoring. This medication can interact with various drugs; therefore, patients should inform their doctor or pharmacist if they are taking other medications. In case of overdose, hypoglycemia or lactic acidosis may occur, so do not change the dosage without a doctor’s instructions, and visit a healthcare facility immediately if any unusual symptoms arise. Caution is required when driving or operating machinery due to the risk of accidents caused by hypoglycemia or dizziness. Lastly, this medication should be kept out of reach of children and should not be transferred to another container for safety.

Serious side effects

Urticaria, severe swelling (edema), difficulty breathing, severe allergic reactions, liver abnormalities (including liver function impairment and jaundice), severe edema, hypoglycemia, lactic acidosis, severe skin reactions, abdominal pain, cardiac arrest, confusion, coma, visual disturbances, paralysis, encephalopathy, thrombocytopenia (including severe forms such as thrombocytopenic purpura), severe neurological symptoms, severe symptoms of hypoglycemia (such as cerebral seizure, loss of consciousness, coma), severe

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal distension
• loss of appetite
• dyspepsia
• constipation
• abdominal pain
• gastrointestinal symptoms
• temporary metallic taste

This medication should be stored in a sealed container to prevent air entry and is best kept at room temperature between 1 degree and 30 degrees Celsius. Storing it this way helps maintain the effectiveness and ensure safe use of the medication.

Appearance

White oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle