Glimel M Tablet 1/250 mg

Adult dose

This medicine is administered 1 to 2 times a day just before or with meals. Each patient's current treatment regimen, effectiveness, and tolerance should be considered when adjusting the dosage, and proper blood glucose monitoring should be conducted. Typically, treatment starts at a low dose, and dosage can be gradually increased based on blood glucose levels and current medications. In clinical trials, the initial daily dose was Glymeperide/Metformin Hydrochloride 2 mg/500 mg.

This medication may cause severe lactic acidosis or hypoglycemia; therefore, treatment should be temporarily suspended if there is a rapid decline in kidney function or signs of dehydration. This medicine should not be used in patients with a kidney function of less than 45 mL/min/1.73 m2, and caution is needed when there are fluctuations in kidney function. In patients at risk of cardiovascular diseases, use of this medicine may be associated with increased cardiovascular mortality, and consultation with a physician is necessary. This medicine should not be administered to patients with insulin-dependent diabetes, acute metabolic acidosis, severe hepatic or renal impairment, pregnant or breastfeeding women. Patients at the beginning of treatment and those at high risk of hypoglycemia (elderly, malnourished, irregular eaters, alcoholics) need to be closely monitored for symptoms of hypoglycemia. Gastrointestinal side effects (diarrhea, nausea, vomiting, etc.) can occur frequently with this medicine, but they are mostly temporary and can be alleviated by taking the medicine with food or by gradually escalating the dosage. Allergic reactions, blood disorders, liver function abnormalities, vitamin B12 deficiency, and other atypical symptoms may occur, and immediate notification to healthcare professionals is required in case of symptom occurrence. Due to many drug interactions, it is essential to inform healthcare professionals when taking other medications or starting new treatments, especially with drugs that affect kidney function. Pregnant or breastfeeding women should not use this medication, and they should consult a doctor if they are planning to conceive or are already pregnant. Caution is advised when administering this medication to children and the elderly; special attention to dosage adjustment and regular kidney function tests is necessary for the elderly due to declining renal function. Symptoms of hypoglycemia include headache, severe hunger, fatigue, drowsiness, confusion, and tremors; if any of these symptoms occur, immediate consumption of sugar and consultation with healthcare professionals are required. Lactic acidosis is rare but can be fatal, so if symptoms such as lethargy, muscle pain, difficulty breathing, or abdominal pain occur, discontinue the medication immediately and seek emergency treatment. Patients should maintain regular meals and exercise, and continuously monitor blood glucose and kidney function during treatment to ensure therapeutic efficacy and safety. In the case of overdose, severe hypoglycemia or lactic acidosis can occur; immediate communication with healthcare professionals and appropriate emergency treatment are necessary. This medicine should be kept out of reach of children and not transferred to other containers for storage.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, liver abnormalities (jaundice), severe neurological symptoms (severe headaches, confusion, paralysis), severe edema or urinary abnormalities, hypoglycemia, lactic acidosis, severe allergic reactions, thrombocytopenic purpura, cardiac arrest.

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, loss of appetite, dyspepsia, constipation, abdominal pain), unpleasant metallic taste, visual impairment, taste disorder, rash, itching, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia, vitamin B12 decrease, increased liver enzymes, liver function impairment, hepatitis, allergic vasculitis, photosensitivity of the skin, serum sodium concentration changes.

This medication should be stored in a tightly sealed container that can block air and moisture, ideally at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

White rectangular film-coated tablet

Package unit

30 tablets/PTP