Glimel M Tablet 2/500 mg

Adult dose

This medication is administered 1–2 times a day immediately before or with meals. The dosage can be adjusted according to each patient's current therapeutic regimen, efficacy, and tolerance. Typically, treatment is started at a low dose and gradually increased based on blood sugar monitoring results. In clinical trials, the initial daily dosage was glymepride/metformin hydrochloride 2 mg/500 mg, with experience increasing it to 8 mg/2000 mg. Glymepride is usually not effective at doses above 4 mg per day, but some patients have shown better metabolic control by increasing to 6 mg (or 8 mg). If used as an alternative therapy in combination therapy, it should be administered based on the current regimen and dosage of glymepride and metformin hydrochloride. Even if a previous dose is missed, do not exceed the single dose at the next administration.

This medication can cause severe lactic acidosis or hypoglycemia, so it should be avoided especially in cases of acute renal dysfunction. If symptoms of dehydration, severe diarrhea, vomiting, or fever occur, it is advisable to temporarily discontinue use of this medication and consult a physician. Patients with decreased renal function or the elderly should have their kidney function checked regularly while using this medication, and it should not be administered if kidney function is below 45 mL/min/1.73 m². Caution is necessary for patients with cardiovascular disease, as this medication may increase the risk of cardiovascular death. Patients with insulin-dependent diabetes, acute metabolic acidosis, severe liver dysfunction, women who are pregnant or breastfeeding, and patients with severe renal impairment should not take this medication. This medication should be discontinued before and after tests using radioactive iodine contrast agents and it should be waited until kidney function returns to normal. Patients at high risk for hypoglycemia, malnourished individuals, those with irregular meal intake, engaging in vigorous exercise, or those consuming alcohol should be carefully monitored when taking this medication. Gastrointestinal disturbances (diarrhea, nausea, vomiting, etc.) are common with this medication, and initially, the dosage may be gradually increased or taken with meals to reduce symptoms. If allergic reactions occur, inform a physician immediately and discontinue use. Regular monitoring of serum vitamin B12 levels is recommended, as vitamin B12 deficiency may occur. This medication may interact with various drugs. If you are taking other medications, you must inform your physician or pharmacist. It is safest not to use this medication during pregnancy or breastfeeding, and insulin therapy should be considered if necessary. Children and the elderly require special caution when using this medication, particularly the elderly, who require careful dosage adjustment and monitoring due to decreased kidney function. In case of overdose, hypoglycemia or lactic acidosis may occur, so contact a medical facility immediately and receive appropriate treatment. While taking this medication, regular meals and exercise, as well as regular blood sugar and kidney function checks, are required, and care should be taken for hypoglycemia symptoms when driving or operating machinery. Keep out of reach of children, and do not transfer to other containers.

Serious side effects

Urticaria, severe swelling (edema), difficulty breathing, hypoglycemia, lactic acidosis, severe allergic reactions, severe skin adverse reactions, hepatic adverse reactions (jaundice), thrombocytopenic purpura, severe neurological symptoms (headache, seizures, altered consciousness, visual disturbances, paralysis), severe edema, cardiac arrest.

Mild side effects

• Nausea
• vomiting
• abdominal distension
• loss of appetite
• dyspepsia
• constipation
• abdominal pain
• taste disturbances
• vision impairment
• erythema

This medication should be stored in a sealed container to protect it from air and moisture. It is recommended to maintain storage temperatures between 1 degree and 30 degrees Celsius.

Appearance

White oblong film-coated tablets

Package unit

30 tablets/PTP