Creameril M Tablet 2/500 mg

Adult dose

This medication is administered 1-2 times a day before meals or with meals. The dosage may be adjusted considering the current treatment regimen, efficacy, and tolerance of each patient, and appropriate blood sugar monitoring should be performed for this purpose. Treatment is typically started at a low dose, and the dosage can be adjusted based on the patient's current medications and blood sugar levels. In clinical trials, the initial daily dose was Glymepride/Metoprolol Hydrochloride.

This medication may cause a risk of severe lactic acidosis or hypoglycemia, so it should be temporarily discontinued and a physician consulted in cases of sudden deterioration of kidney function or dehydration. It should not be used in patients with renal function below 45 mL/min/1.73 m2 and particular caution is necessary in situations where kidney function may change. Reports have associated this medication with increased mortality rates from cardiovascular diseases; therefore, patients should be adequately informed about the risks and benefits of the treatment. It should not be administered to patients with insulin-dependent diabetes, acute metabolic acidosis, severe liver dysfunction, pregnant women, breastfeeding women, or patients with severe kidney impairment. During the initial administration, the risk of hypoglycemia is high, so patients with poor nutritional status or excessive alcohol consumption should be monitored more closely. Gastrointestinal symptoms (diarrhea, nausea, vomiting, etc.) may commonly occur, and if symptoms are severe, administration may be temporarily discontinued. Allergic reactions, hematological abnormalities, and vitamin B12 deficiencies may occur; if abnormal symptoms appear, inform a physician immediately. While taking this medication, regular monitoring of blood sugar, kidney function, and blood tests should be performed. There may be interactions when used in combination with other medications, so patients should inform their physician or pharmacist of all medications they are taking. Pregnant or breastfeeding women should avoid using this medication, and insulin therapy should be initiated if needed. In the case of children or the elderly, dosage adjustment and careful monitoring are needed due to the possibility of decreased kidney function. In the event of overdose, hypoglycemia and lactic acidosis may occur; seek medical attention immediately for appropriate treatment. Caution is required when driving or operating machinery due to hypoglycemia or other side effects.

Serious side effects

Hives, severe swelling, difficulty breathing, severe allergic reactions, severe skin adverse reactions (severe rash, blisters, skin peeling, pain in the oral/eye mucosa), liver abnormalities (liver dysfunction, jaundice), sudden and severe headaches, seizures, altered consciousness, visual disturbances, paralysis, neurological symptoms, decreased urine output, severe systemic edema, high blood pressure, cardiac arrest, severe hypoglycemia, lactic acidosis, shock, sepsis, acute myocardial infarction.

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain), unpleasant metallic taste, vision impairment, taste disorders, nausea, vomiting, upper abdominal bloating or pressure, abdominal pain, diarrhea, palpitations, dizziness, hematological abnormalities (thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia), reduced vitamin B12 and deficiency, intrahepatic enzyme increase.

This medication should be stored in a sealed container to prevent air exposure and kept at room temperature between 1 degree and 30 degrees Celsius for safety. This helps maintain the medication's effectiveness and prevents degradation.

Appearance

White oval film-coated tablets

Package unit

30 tablets/box [(10 tablets/PTP × 3)], 100 tablets/bottle, 30 tablets/bottle