Gliformin Tablets 1/250mg

Adult dose

This medication is administered 1-2 times daily before or with meals. The dosage may be adjusted considering each patient's current treatment regimen, efficacy, and tolerance, with the need for blood sugar monitoring. Generally, treatment begins at a low dose, and adjustments are made based on blood sugar levels and medications in use. In clinical trials, initial dosing was glymepiride/metformin hydrochloride 2mg/500mg daily, followed by monitoring blood sugar levels.

This medication can cause severe lactic acidosis or hypoglycemia; therefore, it should be discontinued and medical advice sought, especially in cases of rapidly declining kidney function. It is advisable to temporarily halt this medication in the event of dehydration symptoms, severe diarrhea, vomiting, or fever, and to inform a doctor. Administration should not occur in patients with kidney function less than 45mL/min/1.73m², and caution is required in situations where kidney function may rapidly change. Patients at risk of cardiovascular disease may have increased mortality associated with the use of this medication; thus, the benefits and risks of treatment should be carefully considered. Insulin-dependent diabetes patients, those with acute metabolic acidosis, severe liver dysfunction, pregnant or breastfeeding women, and patients with severe renal impairment should not receive this medication. During treatment with this medication, there is a risk of hypoglycemia; therefore, elderly patients or those with poor nutritional status, as well as individuals engaging in intense exercise, should carefully monitor blood sugar changes. Gastrointestinal symptoms (diarrhea, nausea, vomiting, etc.) may occur, typically presenting during initial dosing but usually improve over time. If allergic reactions, skin rashes, or hematological abnormalities appear, consult a doctor immediately. This medication may reduce vitamin B12 levels, so regular checks of vitamin B12 status are important with long-term use. During treatment, regular meals, exercise, and consistent monitoring of blood sugar and kidney function are necessary, with consultation for adjustments in treatment methods if blood sugar control is unstable. This medication may have interactions with other drugs; thus, inform your doctor or pharmacist of any ongoing medications. Pregnant women or those planning to become pregnant should not use this medication and should opt for alternative treatments such as insulin therapy. In the event of overdose, serious side effects such as hypoglycemia or lactic acidosis may occur; immediate medical attention is warranted. Children and the elderly require special caution when administered this medication, and thorough monitoring of kidney function and blood sugar levels is essential. This medication should be stored out of reach of children, and it is safe not to transfer it to a different container.

Serious side effects

Urticaria, severe swelling (edema), shortness of breath, chest tightness, severe allergic reactions, liver abnormalities (liver function damage, jaundice), severe neurological symptoms (headache, seizures, consciousness confusion, visual disturbances, paralysis), severe edema, thrombocytopenic purpura, lactic acidosis, hypoglycemia, cardiac arrest.

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal fullness, loss of appetite, indigestion, constipation, abdominal pain), taste disturbances, hematological abnormalities (thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia), peripheral neuropathy due to vitamin B12 deficiency, increased liver enzymes, hepatitis, allergic vasculitis, photosensitivity of the skin, decreased serum sodium, hypothyroidism, during diarrhea.

This medication should be stored in a tightly sealed container to prevent air exposure and kept at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness over time.

Appearance

White oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle