Glipame M Tablet 2/500 mg

Adult dose

This medication is administered 1 to 2 times a day before meals or with meals. Dosage may be adjusted based on each patient's current treatment regimen, effectiveness, and tolerability, with appropriate blood glucose monitoring being necessary. Generally, treatment is initiated at a low dose, adjusting the dose based on the patient's current medication and blood glucose levels. In clinical trials, the initial dose was 2 mg/500 mg of Glimepiride / Metformin Hydrochloride per day, and based on blood glucose monitoring results, the dose can gradually be increased up to 8 mg/2000 mg of Glimepiride / Metformin Hydrochloride. When using as an alternative therapy in combination therapy, it should be administered based on the current dosages and regimens of Glimepiride and Metformin Hydrochloride. If a previous dose was missed, do not take more than the prescribed dose at the next administration.

This medication can cause severe lactic acidosis and hypoglycemia; therefore, it should be discontinued and a physician consulted, especially if kidney function declines sharply. If there is dehydration, severe diarrhea, vomiting, or fever, the use of this medication should be temporarily stopped and medical personnel notified. Patients with poor kidney function or the elderly must test kidney function before taking this medication and regularly monitor kidney function. Patients at risk for cardiovascular disease should be cautious when taking this medication and thoroughly discuss the benefits and risks with healthcare personnel. This medication is contraindicated for patients with insulin-dependent diabetes, acute metabolic acidosis, severe liver dysfunction, pregnant women, and nursing mothers. Before and after tests using radioactive iodine contrast agents, this medication should be temporarily stopped and not retaken until kidney function stabilizes. Patients at high risk for hypoglycemia, malnourished patients, and those consuming excessive alcohol should take additional precautions when using this medication. Gastrointestinal disturbances (diarrhea, nausea, vomiting, etc.) may occur at the beginning of treatment, and patients should consult a doctor if symptoms are severe. During the use of this medication, regular monitoring of blood sugar and glycated hemoglobin is recommended, as well as monitoring of vitamin B12 levels. When used in conjunction with other medications, drug interactions may occur, so all medications being taken should be reported to healthcare personnel. If symptoms of hypoglycemia occur, immediate intake of sugar is necessary, and if symptoms are severe, immediate medical attention is required. Women who are pregnant or planning to become pregnant should consider switching to insulin therapy instead of this medication for safety. The safety and effectiveness of this medication in children and adolescents have not been sufficiently confirmed, thus special caution is necessary when used. Elderly patients commonly have declining kidney function, making dosage adjustment and kidney function tests even more important. Care should be taken when driving or operating machinery, as hypoglycemia or impaired agility may occur.

Serious side effects

Hives, severe swelling (edema), breathing difficulty, severe allergic reactions, liver abnormalities (including jaundice), liver failure, sudden and severe headaches, seizures, confusion of consciousness, paralysis, severe edema, urinary abnormalities, hypoglycemia, lactic acidosis, thrombocytopenic purpura, kidney function abnormalities, cardiac arrest, hypoxia, shock, increased risk of cardiovascular mortality, severe skin adverse reactions

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal bloating
• loss of appetite
• indigestion
• constipation
• abdominal pain
• metallic taste
• visual impairment

This medication should be stored in a tightly closed container to prevent air and moisture from entering, and it is recommended to keep it at a temperature between 1 degree and 30 degrees Celsius. This storage method helps maintain the effectiveness of the medication and prevents degradation.

Appearance

White oblong film-coated tablet

Package unit

30 tablets/bottle