Gliphosin M Tablet 2/500 mg

Adult dose

This medication is administered once or twice daily before meals or with meals. The dosage can be adjusted considering the patient's current therapy, effectiveness, and tolerability, along with proper blood glucose monitoring. The initial daily dosage is started at 2 mg of glimepiride/metformin hydrochloride 500 mg, and gradually increased based on blood glucose monitoring results. The maximum dosage is 8 mg of glimepiride/metformin hydrochloride 2000 mg.

This medication can cause severe lactic acidosis or hypoglycemia, and it may be dangerous, especially if kidney function is rapidly declining. If dehydration, severe diarrhea, vomiting, or fever occurs, the medication should be temporarily discontinued, and consultation with a doctor is necessary. Patients with impaired kidney function or taking drugs that may affect kidney function should exercise special caution when using this medication. This drug may increase the risk of cardiovascular mortality, so both patients and caregivers should thoroughly understand its risks and benefits. Insulin-dependent diabetes patients, acute metabolic acidosis patients, patients with severe liver disease, pregnant or breastfeeding women, and patients with severe kidney impairment should not use this medication. Especially, the administration of this medication should be suspended before and after procedures using iodine contrast agents, and it should not be re-administered until kidney function stabilizes. Patients at high risk of hypoglycemia, those in a state of malnutrition, elderly individuals, and patients with liver failure should use this medication cautiously while closely monitoring blood sugar levels during the initial dosing period. Gastrointestinal disturbances (such as diarrhea, nausea, vomiting) may occur during the use of this medication, most of which are temporary, but if severe, medical consultation is recommended. Allergic reactions or hematological abnormalities may arise, so any unusual symptoms should be promptly reported to a doctor. This medication may decrease vitamin B12 levels, so it is necessary to regularly check vitamin B12 status during long-term use. During diabetes treatment, blood glucose and glycosylated hemoglobin levels should be regularly tested to monitor therapeutic effects, and medication dosage adjustments may be necessary with lifestyle changes or the occurrence of other diseases. Excessive alcohol consumption should be avoided during treatment with this medication, and precautions should be taken when driving or operating machinery due to potential decreased alertness from hypoglycemia or hyperglycemia. During pregnancy or breastfeeding, insulin therapy is recommended instead of this medication, and special attention is needed for children and the elderly. Overdose may result in hypoglycemia or lactic acidosis; immediate medical attention should be sought for proper treatment. This medication may interact with several other drugs, so it is important to inform the physician or pharmacist if taking other medications. This medication should be kept out of reach of children and should not be transferred to another container.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, chest tightness, severe edema accompanied by increased blood pressure, high fever with severe rash, blisters, skin peeling, pain in the oral/ocular mucosa, jaundice of the skin or eyes, generalized lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, significantly reduced urine output, lactic acidosis, thrombocytopenic purpura, severe hypoglycemia, cardiac arrest, severe

Mild side effects

• Nausea
• vomiting
• abdominal bloating
• loss of appetite
• indigestion
• constipation
• abdominal pain
• taste disturbance
• visual impairment
• erythema

This medication should be stored in a tightly closed container to prevent air and moisture from entering, preferably at a temperature between 1 and 30 degrees Celsius. Proper storage helps maintain the drug's efficacy and prevent degradation.

Appearance

White oblong film-coated tablet

Package unit

30 tablets (10 tablets/PTP x 3)