GlimeMed M Tablets 2/500 mg

Adult dose

This medication is administered 1-2 times daily before meals or with meals. The dose may be adjusted considering each patient's current treatment regimen, efficacy, and tolerance, which requires appropriate blood sugar monitoring. A low initial dose is conventionally started, and the dosage may be adjusted based on the patient’s current medications and blood sugar levels. In clinical trials, the initial daily dose was 2 mg/500 mg of glimepiride/metformin hydrochloride.

This medication can cause severe lactic acidosis or hypoglycemia, so patients should discontinue use and consult a doctor, especially if kidney function has significantly declined. In cases of dehydration, severe diarrhea, vomiting, or fever, temporarily halt the use of this medication and inform healthcare providers. Patients with cardiovascular disease risk should exercise caution with this medication, and blood sugar levels and cardiovascular status should be monitored regularly during treatment. This medication is not for use in patients with insulin-dependent diabetes, acute metabolic acidosis, severe liver or kidney function impairment, or in pregnant or breastfeeding women. At the beginning of treatment, there is a high risk of hypoglycemia, so it is crucial to maintain regular eating habits and immediately consume sugar if hypoglycemic symptoms occur. This medication may cause gastrointestinal disturbances (diarrhea, nausea, vomiting, etc.), and if symptoms are severe, consult a doctor. If any allergic reactions or skin rashes, or symptoms such as difficulty breathing occur, inform healthcare providers immediately. Regular testing of kidney function, blood sugar, and Vitamin B12 levels is necessary to ensure there are no anomalies, and extra caution is advised for the elderly or those with impaired kidney function. There may be interactions with other medications, so inform healthcare providers of all medications being taken, and it is advisable to avoid alcohol consumption. If planning a pregnancy or currently pregnant, this medication should not be used, and insulin therapy should be switched for blood sugar control. Safety and efficacy have not been established for children and adolescents, so administering the drug should be done cautiously. In cases of overdose, hypoglycemia or lactic acidosis may occur, requiring immediate medical attention. Patients should exercise caution when driving or operating machinery due to the risk of accidents from hypoglycemia or dizziness. This medication should be stored out of reach of children and not transferred to other containers.

Serious side effects

• Hives.
• Severe lactic acidosis.
• Hypoglycemia.
• Difficulty breathing.
• Severe skin reactions: severe rash, blisters, skin peeling, pain in mouth/eyes mucosa.
• Liver abnormalities (jaundice): yellowing of skin or eyes, extreme lethargy.
• Severe neurological symptoms: sudden and extremely severe headaches, confusion, visual disturbances, paralysis.
• Severe swelling or urination abnormalities: pronounced swelling throughout the body, significantly decreased urine output.
• Cardiac arrest.
• Thrombocytopenia.

Mild side effects

• Gastrointestinal symptoms: diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain, or a feeling of fullness or pressure in the upper abdomen.
• Specific sensory symptoms: metallic taste, transient visual impairment, taste disorder.
• Skin reactions: erythema, itching, rash.
• Hematological abnormalities: thrombocytopenia, leukopenia, hemolytic anemia, anemia, granulocytopenia, agranulocytosis, pancytopenia.
• Others: decreased and deficiency of Vitamin B12, hepatic.

Store this medication in a tightly closed container to prevent air and moisture penetration, and keep it in a cool room temperature between 1 to 30 degrees Celsius.

Appearance

White rectangular film-coated tablets

Package unit

30 tablets/bottle