Grimarin M Tablet 2/500 mg

Adult dose

This medication is administered 1 to 2 times daily just before or with meals. Dosage may be adjusted according to each patient’s current therapy, efficacy, and tolerability; appropriate blood sugar monitoring should be conducted for this purpose. Treatment is generally started at a low dose, and dosing may be adjusted based on the patient’s current medication and blood sugar levels. In clinical trials, the initial daily dose was glimepiride/metformin hydrochloride.

This medication may cause severe lactic acidosis or hypoglycemia; thus, treatment must be discontinued if there is a rapid decline in renal function. If symptoms of dehydration, severe diarrhea, vomiting, or fever occur, it is advisable to temporarily stop taking this medication and consult a physician. Patients with compromised renal function or elderly patients should be particularly cautious and undergo regular kidney function tests. Patients at risk of cardiovascular diseases should consult their doctor since taking this medication may increase cardiovascular mortality. Patients with insulin-dependent diabetes, acute metabolic acidosis, or severe liver or kidney dysfunction should not take this medication. Pregnant or breastfeeding women should also avoid using this medication for safety. Elderly patients, malnourished individuals, irregular eaters, and alcohol consumers at high risk of hypoglycemia should be closely monitored for hypoglycemic symptoms while taking this medication. At the start of treatment, gastrointestinal side effects (such as diarrhea, nausea, vomiting, etc.) may occur, but these are mostly temporary and symptoms may improve when taken with meals. If allergic reactions or skin rashes occur, inform a physician immediately, and discontinue use in severe cases. This medication may decrease vitamin B12 levels, so regular monitoring of serum vitamin B12 levels is necessary during long-term use. Interactions may occur when used with other medications, so all medications being taken should be reported to a doctor or pharmacist for caution. In case of overdose, hypoglycemia or lactic acidosis may occur, so immediate medical attention is required for appropriate treatment. Caution is needed while driving or operating machinery, as hypoglycemia or dizziness may present. The safety of this medication in children has not been established; therefore, special caution is needed when administering to minors.

Serious side effects

• Hives, severe swelling, chest tightness, difficulty breathing, cold sweats, pallor, severe allergic reactions.
• Severe rash, blisters, skin peeling with high fever, pain in oral/ocular mucosa, severe skin adverse reactions.
• Shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough + fever.
• Skin or eyes turning yellow (jaundice), severe lethargy, liver abnormalities (jaundice).
• Sudden and very severe headache, lightning-type headache.

Mild side effects

Diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain, unpleasant metallic taste, visual impairment, taste disorder, erythema, itching, rash, nausea, vomiting, fullness or pressure in the upper abdomen, diarrhea, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia, decreased vitamin B12, increased hepatic enzymes, hepatitis, allergic vasculitis, photosensitivity.

Store this medication in a tightly sealed container that is air-tight, preferably at room temperature between 1 and 30 degrees Celsius. Proper storage will maintain the medication's effectiveness and prevent deterioration.

Appearance

White oblong film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle