Esol Tablet 40 mg (Olmesartan Medoxomil)

Adult dose

The recommended initial dose is 10 mg once daily, taken regardless of meals. If blood pressure is not adequately controlled, it can be increased to 20 mg once daily. If additional blood pressure reduction is required, it can be increased to a maximum of 40 mg once daily. The blood pressure-lowering effect is observed within two weeks of starting treatment, with maximum effect occurring in about eight weeks. If blood pressure control is not achieved with monotherapy, combination therapy with thiazide diuretics such as hydrochlorothiazide may be considered. To improve adherence, it is recommended to take it at the same time each day (e.g., in the morning). In patients with potential intravascular volume depletion (e.g., patients on diuretics, especially those with renal impairment), it is advisable to start treatment at a lower dose and closely monitor their condition. <For the elderly> When administering this drug to elderly patients aged 65 and older, dose adjustment is not required. Overall differences in efficacy and safety between elderly and younger patients have not been observed, but it cannot be excluded that some elderly patients may exhibit a more sensitive response. <For patients with renal impairment> The maximum dose for patients with mild to moderate renal impairment (creatinine clearance 20-60 mL/min) is 20 mg once daily. <For patients with liver impairment> Mild liver impairment does not require dosage adjustment. Patients with moderate liver impairment should start at a recommended initial dose of 10 mg once daily and can be increased to a maximum of 20 mg daily. There is no experience with severe liver impairment, so this drug is not recommended for such patients. <For children> The safety and efficacy in children have not been established.

Child dose

The safety and efficacy in children have not been established.

This medication can cause serious harm or death to the fetus or newborn if taken during the second and third trimesters of pregnancy, so it should be discontinued immediately upon confirmation of pregnancy. Patients with allergies to the ingredients of this drug, pregnant women, breastfeeding women, patients undergoing renal dialysis, patients with severe liver dysfunction, and patients with biliary obstruction should not use this drug. Additionally, patients with hereditary metabolic disorders such as lactose intolerance should not take this medication. When administering this drug for the treatment of hypertension, caution is needed as patients with low blood volume or salt may experience hypotension, and appropriate measures should be taken immediately if symptoms occur. Patients with impaired kidney function or who have received kidney transplants should regularly monitor and manage potassium and creatinine levels in the blood. As this drug has an effect of lowering blood pressure, dizziness may occur; therefore, it is advisable to avoid hazardous activities such as working at heights or driving. This drug can cause hyperkalemia, so particularly patients with heart failure or reduced kidney function should frequently check serum potassium levels. If gastrointestinal disorders such as chronic diarrhea occur, the use of this drug should be discontinued and a physician consulted, and symptoms of intestinal vascular swelling should also be closely monitored. The blood pressure-lowering effect may be increased when this drug is taken with other antihypertensives, and the co-administration of potassium-sparing diuretics or potassium supplements can dangerously elevate serum potassium levels. Lithium preparations should not be taken together, as co-administration may lead to elevated lithium levels and toxicity. When taken with non-steroidal anti-inflammatory drugs, there is a risk of deteriorating renal function, so kidney function should be monitored regularly. Taking this drug during pregnancy can lead to serious problems such as decreased kidney function in the fetus, oligohydramnios, and cranial developmental delays, so it should be discontinued immediately upon learning of pregnancy. Breastfeeding women should consider that this drug may be passed into breast milk, so they should discontinue breastfeeding or the medication to prevent adverse reactions in the baby. The safety and efficacy in children have not been sufficiently established, so it is generally not administered to children. In case of overdose, hypotension and palpitations may occur, and appropriate emergency treatment should be obtained if necessary.

Serious side effects

Hives, severe swelling (angioedema), chest pain, anaphylaxis, severe rash with fever, blisters, skin peeling, pain in mouth/eye mucosa, difficulty breathing or shortness of breath, asthma attack, respiratory issues accompanied by cough and fever, jaundice (yellowing of the skin or eyes), liver dysfunction, sudden and severe headache, seizures, confusion, visual disturbances, paralysis, significantly decreased urine output, peripheral edema,

Mild side effects

• Dizziness
• headache
• palpitations
• low back pain
• hematuria
• hyperglycemia
• hypertriglyceridemia
• flu-like symptoms
• pharyngitis
• rhinitis

This medication should be stored in a tightly closed container to protect it from air and light. It is important to maintain a storage temperature between 1 and 25 degrees Celsius, as this helps to preserve the drug's efficacy and safety over time.

Appearance

White oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle