Mesar 20 mg (Olmesartan Medoxomil)

Adult dose

The recommended initial dose is 10 mg once daily, regardless of meals. If blood pressure is not adequately controlled at this dose, it may be increased to 20 mg once daily. If additional blood pressure-lowering effects are needed, the dose may be increased to a maximum of 40 mg once daily. The hypotensive effect typically occurs within 2 weeks of starting treatment and reaches its maximum effect in approximately 8 weeks. If blood pressure is not controlled with this medication alone, thiazide diuretics such as hydrochlorothiazide may be used in combination. To improve adherence, it is recommended to take it at the same time each day (e.g., in the morning). It is advised to start treatment at a low dose while closely monitoring the status of patients at risk of intravascular volume depletion (e.g., patients on diuretics, particularly those with renal impairment). <For elderly patients> When administering this medication to older patients aged 65 years and older, dose adjustment is not necessary. No significant overall differences in efficacy and safety have been observed between older and younger patients, although some older patients may exhibit more sensitive responses. <For patients with renal impairment> The maximum dosage for patients with mild to moderate renal impairment (creatinine clearance 20-60 mL/min) is 20 mg once daily. <For patients with liver impairment> Dose adjustment is not necessary for patients with mild liver impairment. For patients with moderate liver impairment, the recommended initial dose is 10 mg once daily, which can be increased to a maximum of 20 mg once daily. There is no experience with severe liver impairment patients, so use is not recommended. <For pediatric patients> Safety and effectiveness in pediatric patients have not been established.

Child dose

Safety and effectiveness in pediatric patients have not been established.

This medication may cause serious harm to the fetus and newborn if taken during the second and third trimesters of pregnancy; therefore, it should be discontinued immediately upon confirmation of pregnancy. Patients with allergies to any ingredients in this medication, those who are pregnant or breastfeeding, patients on kidney dialysis, severely impaired liver function patients, patients with bile duct obstruction, and those with lactose intolerance should not take this medication. Patients with low blood volume or sodium may experience hypotension, so their condition should be carefully checked before administration and monitored closely after. Severe heart failure or patients with kidney function issues may experience worsening kidney function, so frequent blood tests to monitor kidney status are necessary. This medication may cause hyperkalemia, so patients with heart disease or kidney disease should closely monitor their serum potassium levels. Dizziness may occur, so it is advisable to avoid driving or operating hazardous machinery. The blood pressure-lowering effect may be enhanced if this medication is taken with other antihypertensive drugs; thus, it is crucial to inform your healthcare provider of any other medications you are taking. Caution is necessary when taken with potassium-sparing diuretics or potassium supplements, as blood potassium levels may become dangerously high. When taken with lithium, it may increase lithium levels and cause toxicity, so co-administration is not advisable. Taking non-steroidal anti-inflammatory drugs (NSAIDs) with this medication can worsen kidney function, requiring adequate hydration and kidney function monitoring. Taking this medication during pregnancy can have fatal consequences for the fetus; therefore, if you are planning to become pregnant or are pregnant, consult your doctor. If breastfeeding, this medication may be transferred to breast milk, putting the infant at risk for adverse reactions, so it may be necessary to discontinue breastfeeding or stop taking this medication. Safety for pediatric patients has not been established, so it is preferable for children not to use this medication. Older adults may experience increased drug concentration, and caution is advised when administering this medication. In cases of overdose, symptoms such as hypotension and palpitations may occur; any symptoms should be reported to healthcare professionals immediately, and appropriate treatment is required. Although no carcinogenic risk has been reported with long-term use of this medication, rare side effects such as liver function abnormalities, skin rashes, and angioedema may occur; consult healthcare professionals immediately if any unusual symptoms arise.

Serious side effects

• Urticaria
• angioedema
• anaphylaxis
• intestinal angioedema
• rhabdomyolysis
• hyperkalemia
• acute renal failure
• elevated serum creatinine
• abnormal liver function tests
• autoimmune hepatitis

Mild side effects

• Dizziness
• headache
• palpitations
• lower back pain
• bronchitis
• diarrhea
• hematuria
• hyperglycemia
• hypertriglyceridemia
• flu-like symptoms

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, it is important to store the medication at room temperature, between 1 and 25 degrees Celsius, to maintain its efficacy.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle