Daehan Olmesartan Tablets 20mg (Olmesartan Medoxomil)

Adult dose

The recommended initial dose is 10mg once a day, taken irrespective of meals. If blood pressure is not adequately controlled, the dose may be increased to 20mg once a day. If additional blood pressure reduction is needed, the dose may be increased up to a maximum of 40mg once a day. Blood pressure-lowering effects generally appear within 2 weeks after starting treatment, with maximum effects observed approximately 8 weeks later. If blood pressure is not adequately controlled with monotherapy, a thiazide diuretic such as hydrochlorothiazide can be used in combination. To improve adherence, it is recommended to take the medication at the same time each day (for example, in the morning). For patients who may experience intravascular volume depletion (e.g., those receiving diuretics, especially with kidney damage), close observation of the condition while starting at a low dose is advised. <For Elderly> No dose adjustment is necessary when administering this medication to elderly patients aged 65 and over. No overall differences in efficacy and safety have been observed between elderly and younger patients, although some elderly individuals may exhibit more sensitive responses. <For Renal Impaired Patients> The maximum dose for patients with mild to moderate renal impairment (creatinine clearance 20-60mL/min) is 20mg once daily. <For Hepatic Impaired Patients> Patients with mild liver impairment do not require dose adjustment. For those with moderate liver impairment, the recommended initial dose is 10mg once daily, which may be increased to a maximum of 20mg daily. Experience with severe liver impairment is lacking, hence use is not recommended. <For Children> Safety and efficacy in pediatric patients have not been established.

Child dose

Safety and efficacy in pediatric patients have not been established.

This medication can cause serious harm to the fetus and newborn if taken during the second and third trimesters of pregnancy, thus it must be discontinued immediately upon confirmation of pregnancy. It should not be used by individuals with allergies to any of the components, pregnant or breastfeeding women, patients on renal dialysis, patients with severe liver disorders, and those with bile duct obstruction. Additionally, individuals with lactose intolerance or specific hereditary lactose degradation enzyme deficiencies should not take this medication. Patients with reduced blood volume or sodium, impaired kidney function, renal artery hypertension, those at risk for hyperkalemia, patients with aortic and mitral stenosis should use this medication cautiously, monitoring blood pressure and kidney function regularly. This medication may cause side effects such as dizziness; therefore, caution should be taken when operating heavy machinery or driving. While taking this medication, there may be side effects or changes in efficacy if combined with potassium-sparing diuretics, potassium supplements, lithium, non-steroidal anti-inflammatory drugs, so consultation with a physician is advisable. If a pregnant woman takes this medication, serious issues can arise for the fetus, including hypotension, kidney damage, and reduced amniotic fluid; thus, it must not be taken during pregnancy unless strictly managed by a specialist. Breastfeeding women should avoid this medication due to the risk of transmission through breast milk, which may cause side effects in infants, and should either discontinue breastfeeding or stop taking the medication. Safety for pediatric use has not been established, and its use in children is not recommended. In case of overdose, symptoms such as hypotension or palpitations may occur, requiring immediate treatment if necessary. Long-term use of this medication is known to present a low risk of carcinogenicity or genotoxicity; however, if any unusual symptoms arise while taking it, immediate consultation with healthcare personnel is necessary.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, severe skin reactions, shortness of breath or difficulty in breathing, asthma attack, respiratory issues accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, liver abnormalities (jaundice), sudden

Mild side effects

Dizziness, headache, palpitations, hypercholesterolemia, hyperlipidemia, hyperuricemia, joint pain, arthritis, myalgia, rash, vomiting, chronic malabsorption syndrome-like intestinal disease, hair loss, itching, cough, nosebleed, upper respiratory infection, asthma, increased blood pressure, back pain, abdominal pain, diarrhea, chest pain, peripheral edema, hematuria, flu-like symptoms, pharyngitis, rhinitis, sinusitis, increased creatine phosphokinase

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 to 25 degrees Celsius.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle